SEARCH

SEARCH BY CITATION

Keywords:

  • Anticonvulsants–;
  • Tiagabine–;
  • Drug toxicity–;
  • Drug screening–;
  • Preclinical drug evaluation–;
  • Controlled clinical trials–;
  • Pharmacokinetics–;
  • Drug interaction

Summary: Tiagabine (TGB), a specific γ-aminobutyric acid (GABA)-uptake inhibitor, is a potential new antiepileptic drug with a novel mechanism of action. In animal models of epilepsy as well as in a placebo-controlled trial in patients with complex partial seizures, TGB showed significant anticonvulsant effects. TGB was well tolerated by most patients.