Cytokine Production in Blood Mononuclear Cells from Epileptic Patients
Article first published online: 3 AUG 2005
Volume 36, Issue 4, pages 384–387, April 1995
How to Cite
Pacifici, R., Paris, L., Di Carlo, S., Bacosi, A., Pichini, S. and Zuccaro, P. (1995), Cytokine Production in Blood Mononuclear Cells from Epileptic Patients. Epilepsia, 36: 384–387. doi: 10.1111/j.1528-1157.1995.tb01013.x
- Issue published online: 3 AUG 2005
- Article first published online: 3 AUG 2005
- Received February 1994; revision accepted July 1994.
- Blood cells
Summary Although convulsive disorders have been associated with immune abnormalities, little is known about cytokine production in epileptic patients. We evaluated the concentrations of interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-2 (IL-2), and interleukin-6 (IL-6) secreted by peripheral blood mononuclear cells (PBMC) from epileptic patients. The PBMC collected from epileptic patients, as compared with those of a control group, showed greater production of IL-1α, IL-1β, and IL-6 in response to in vitro stimulation with mitogen. There was no statistical difference among patients treated with different antiepileptic drugs (AEDs). Significantly greater IL-2 production was observed in PBMC from carbamazepine (CBZ)-treated patients as compared with both the control group or with valproate and phenobarbital (PB)-treated patients.