Functional Neuroimaging with Positron Emission Tomography
Version of Record online: 3 AUG 2005
Volume 37, Issue 12, pages 1141–1154, December 1996
How to Cite
Henry, T. R. (1996), Functional Neuroimaging with Positron Emission Tomography. Epilepsia, 37: 1141–1154. doi: 10.1111/j.1528-1157.1996.tb00546.x
- Issue online: 3 AUG 2005
- Version of Record online: 3 AUG 2005
- Accepted June 4, 1996.
- Positron emission tomography;
- Neuroimaging Epilepsy
Summary: Epilepsy research using positron emission tomography (PET) has provided considerable new information about ictal and interictal dysfunctions in human epilepsy. Neuroreceptor mapping with PET ligands has revealed altered central benzodiazepine receptor and opiate receptor densities in partial epilepsies interictally, and regional increases in endogenous opioid peptide concentrations during absence seizures. Imaging of perfusion and glucose metabolism during cognitive processing has shown interictal abnormalities of regional activation in partial and generalized epilepsies. The diagnostically robust patterns of interictal glucose hypometabolism are not adequately explained by macrostructural and microstructural alterations in temporal lobe epilepsy. Current investigations of the pathophysiology of interictal hypometabolism must address ultrastructural and neurochemical factors. Clinical PET in pre-surgical evaluation of medically refractory epilepsies remains an active area of research, but remarkably little antiepileptic drug research has exploited PET techniques.