• 1
    Freeman JM, Kelly MT, Freeman JB. The epilepsy diet treatment. New York : Demos Publications, 1994.
  • 2
    Keith HM. Convulsive disorders in children: with reference to treatment with ketogenic diet. Boston : Little, Brown, 1963.
  • 3
    Livingston S. Dietary management of epilepsy. In: Livingston S. Comprehensive management of epilepsy in infancy, childhood and adolescence. Springfield , IL : Charles C Thomas 1972:378405.
  • 4
    Kinsman SL, Vining EPG, Quaskey SA, Mellits D, Freeman JM. Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 1992;33:11326.
  • 5
    Nigro MA, Ventimiglia J, Selcen D, Beierwaltes P. Seizure frequency, behavioral, and performance effects of the ketogenic diet. Ann Neurology 1995;38:54950.
  • 6
    Uhlemann ER, Neims AH. Anticonvulsant properties of the ketogenic diet in mice. J Pharmacol Exp Ther 1972;180:2318.
  • 7
    Appleton DB, de Vivo DC. An animal model for the ketogenic diet. Epilepsia 1974;15:2117.
  • 8
    Nakazawa M, Kodama S, Matsuo T. Effects of ketogenic diet on electroconvulsive threshold and brain contents of adenosine nucleotides. Brain Dev 1983;5:37580.
  • 9
    Mike EM. Practical guide and dietary management of children with seizures using the ketogenic diet. Am J Clin Nutr 1965;17: 399409.
  • 10
    Hori A, Tandon P, Holmes GL, Stafstrom CE. Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia 1997;38:750758.
  • 11
    Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clin Proc 1921;2:3078.
  • 12
    Geyelin HR. Fasting as a method for treating epilepsy. Med Rec 1921;99:10379.
  • 13
    Dodson WE, Prensky AL, de Vivo DC, Goldring S, Dodge PR. Management of seizure disorders: selected aspects. Part 11. J Pediatr 1976;89:695703.
  • 14
    Gerhardt C. Diabetes Mellitus und Aceton. Wien Med Presse 1865; 6:B28.
  • 15
    Lynen F. Acetyl coenzyme A and the ‘fatty acid cycle. The Harvey lectures 1953;28:210.
  • 16
    Cahill GF, Herrera MG, Morgan AP, et al. Hormone-fuel relationships during fasting., J Clin Invest 1966;45:17511847.
  • 17
    Owen OE, Morgan AP, Kemp HG, Sullivan JM, Henera MG, Cahill GF. Brain metabolism during fasting. J Clin Invest 1967; 46:158995.
  • 18
    Appleton DB, de Vivo DC. An animal model for the ketogenic diet: electroconvulsive threshold and biochemical alterations consequent upon a high-fat diet. Epilepsia 1974; 15:21127.
  • 19
    de Vivo DC, Leckie MP, Ferrendelli JS, McDougal DB. Chronic ketosis and cerebral metabolism. Ann Neurol 1978;3:3317.
  • 20
    Al-Mudallal AS, La Manna CJ, Lust D, Harik SI. Diet-induced ketosis does not cause cerebral acidosis. Epilepsia 1996;37:25861.
  • 21
    de Vivo DC, Trifiletti RR, Jacobson RI, Ronen GM, Behmand RA, Harik SI. Defective glucose transport across the blood-brain bamer as a cause of persistent hypoglycorrhachia, seizures, and development delay. N Engl J Med 1991;325:7039.
  • 22
    Falk RE, Cederbaum SD, Blass JP, Gibson GE, Kark RA, Carrel RE. Ketogenic diet in the management of pyruvate dehydrogenase deficiency. Pediatrics 1976;58:71321.
  • 23
    Wexler ID, Hemalatha SG, McConnell J, et al. Outcome of pymvate dehydrogenase deficiency treated with ketogenic diets: studies in patients with identical mutations. Neurology 1997 (in press).
  • 24
    Peterman MG. The ketogenic diet in epilepsy. JAMA 1925;84: 17971882.
  • 25
    Lennox WG. Ketogenic diet in the treatment of epilepsy. N Engl J Med 1928;199:745.
  • 26
    Millichap JG, Jones JD, Rudis BP. Mechanism of anticonvulsant action of ketogenic diet. Studies in animals with experimental seizures and children with petit ma1 epilepsy. Am J Dis Child 1964; 107:593604.
  • 27
    Persson B, Settergren G, Dahlquist G. Cerebral arterio-venous difference of acetoacetate and D-beta-hydroxybutyrate in children. Acta Paediatr Scand 1972;61:2738.
  • 28
    Haymond MW, Howard C, Ben-Galim E, de Vivo DC. Effects of ketosis on glucose flux in children and adults. Am J Physiol 1983; 245:E3738.
  • 29
    Nordli DR, Koenigsberger D, Carroll J, de Vivo DC. Successful treatment of infants with the ketogenic diet. Ann Neurol 1995;38: 523.
  • 30
    Hawkins RA, Biebuyck. Regional brain utilization of ketone bodies. In: PassonneauJV, HawkinsRA, LustWD, WelshFA, eds. Cerebral metabolism and neural function. Baltimore : Williams & Wilkins, 1980:25563.
  • 31
    Fay T. The therapeutic effect of dehydration on epileptic patients. Arch Neurol Psychiatry 1930;23:92045.
  • 32
    Haymond MW, Karl IE, Clarke WL, Pagliara AS, Santiago JV. Differences in circulating gluconeogenic substrates during short-term fasting in men, women and children. Metabolism 1982;31: 3342.
  • 33
    de Vivo DC, Pagliara AS, Prensky AL. Ketotic hypoglycemia and the ketogenic diet. Neurology 1973;23:6409.
  • 34
    Temkin NR, Dikmen SS, Wilensky AJ, et al. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. N Engl J Med 1990;323:497502.
  • 35
    Silver JM, Shin C, McNamara JO. Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy. Ann Neurol 1991;29:35663.
  • 36
    Hahn TJ, Halstead LR, de Vivo DC. Disordered mineral metabolism produced by ketogenic diet therapy. Calcif Tissue Int 1979: 28:1722.
  • 37
    de Vivo DC, Haymond MW, Leckie MP, Bussman YL, McDougal DB, Pagliara AS. The clinical and biochemical implications of pyruvate carboxylase deficiency. J Clin Endocrinol Metab 1977; 45:128196.
  • 38
    Chez MG, Buchanon C, Kessler J, Demski P, Wagner E. Cmitine defiency in patients starting the ketogenic diet. Neurology 1997; 48:AllO.
  • 39
    McGarry JD, Robles-Valdes C, Foster DW. Role of carnitine in hepatic ketogenesis. Proc Natl Acad Sci 1975;72:43858.
  • 40
    Demeritte EL, Ventimiglia J, Coyne M, Nigro MA. Organic acid disorders and the ketogenic diet. Ann Neurol 1996;40:305.
  • 41
    de Vivo DC. How to use other drugs (steroids) and the ketogenic diet. In: MorselliPL, PippengerCE, PenryJK, eds. Antiepileptic drug therapy in pediatrics. New York Raven Press, 1983:28393.