Presented in part at the Annual Meeting of the Child Neurology Society, Minneapolis, Minnesota, September 26–28, 1996.
Complications of the Ketogenic Diet
Article first published online: 3 AUG 2005
Volume 39, Issue 7, pages 744–748, July 1998
How to Cite
Ballaban-Gil, K., Callahan, C., O'Dell, C., Pappo, M., Moshé, S. and Shinnar, S. (1998), Complications of the Ketogenic Diet. Epilepsia, 39: 744–748. doi: 10.1111/j.1528-1157.1998.tb01160.x
- Issue published online: 3 AUG 2005
- Article first published online: 3 AUG 2005
- Accepted February 17, 1998.
- Ketogenic diet;
Summary: Purpose: The ketogenic diet has been successfully used in treatment of pediatric epilepsy for >70 years. Few serious complications caused by the diet have been reported. We report complications that have been experienced by children receiving the ketogenic diet.
Methods: In a 22-month period, we treated 52 children with the classic ketogenic diet and monitored them in a prospective manner.
Results: Five children (10%) experienced serious adverse events (AE) after initiation of the diet. Four patients (80%) were treated with valproate (VPA) in addition to the diet, as compared with 25 (53%) of the other 47 children. Two patients developed severe hypoproteinemia within 4 weeks of initiation of the diet, and 1 of them also developed lipemia and hemolytic anemia. A third child developed Fanconi's renal tubular acidosis within 1 month of diet initiation. Two other children manifested marked increases in liver function tests, 1 during the initiation phase and the other 13 months later.
Conclusions: Clinicians who wish to use the ketogenic diet must be aware of the potential of serious AE and possible interactions of the diet with VPA.