Ketosis and Epilepsy: 31P Spectroscopic Imaging at 4.1 T
Article first published online: 2 AUG 2005
Volume 40, Issue 6, pages 703–707, June 1999
How to Cite
Pan, J. W., Bebin, E. M., Chu, W. J. and Hetherington, H. P. (1999), Ketosis and Epilepsy: 31P Spectroscopic Imaging at 4.1 T. Epilepsia, 40: 703–707. doi: 10.1111/j.1528-1157.1999.tb00766.x
- Issue published online: 2 AUG 2005
- Article first published online: 2 AUG 2005
- Accepted November 6, 1998.
- 31P spectroscopy;
Summary: Purpose: To determine whether changes in the high-energy phosphates occur with use of the ketogenic diet in patients with intractable epilepsy.
Methods:31P magnetic resonance spectroscopic imaging studies were performed at 4.1 T in seven patients with intractable epilepsy (four Lennox-Gastaut syndrome, one absence, one primary generalized tonic-clonic, and one partial complex) before and after institution of the ketogenic diet. Coronal 1H anatomic imaging also was performed to provide correlation to the 31P data.
Results: Taking the patients as a group, the ratio of phosphocreatine (PC)/γ-adenosine triphosphate (ATP) measured at baseline (regular diet) compared with that measured after the ketogenic diet showed a small but significant increase from 0.61 ± 0.08 to 0.69 ± 0.08 (p < 0.05). Comparing the ratio of PCr inorganic phosphorus (Pi) measured at baseline with the postketogenic diet, there was a significant increase from 2.45 ± 0.27 to 2.99 ± 0.44 (p < 0.05).
Conclusions: As a group, improvement of energy metabolism occurs with use of the ketogenic diet. This is in agreement with the chronic ketosis studies performed earlier in rodents.