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Basic Mechanisms of Monogenic Inheritance

  1. Andreas Ziegler*

Article first published online: 2 AUG 2005

DOI: 10.1111/j.1528-1157.1999.tb00891.x

Issue

Epilepsia

Epilepsia

Volume 40, Issue Supplement s3, pages 4–8, March 1999

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How to Cite

Ziegler, A. (1999), Basic Mechanisms of Monogenic Inheritance. Epilepsia, 40: 4–8. doi: 10.1111/j.1528-1157.1999.tb00891.x

Author Information

  1. Institut für Immungenetik, Universitätsklinikum Charité, Humboldt-Universität zu Berlin, Berlin, Germany

*Address correspondence and reprint requests to Prof. Dr. A. Ziegler at Institut für Immungenetik, Universitätsklinikum Charité, Campus Virchow-Klinikum, Humboldt-Universität zu Berlin, Spandauer Damm 130, D-14050 Berlin, Germany. E-mail: andreas.ziegler@charite.de

Publication History

  1. Issue published online: 2 AUG 2005
  2. Article first published online: 2 AUG 2005

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Keywords:

  • Mendelian inheritance;
  • Genotype;
  • Phenotype;
  • Genome analysis;
  • Gene linkage

Summary:

To revive the appreciation of the importance of genetic studies for the understanding of neurologic diseases inherited in a monogenic fashion. After a description of the basic patterns of monogenic inheritance, the importance of linkage studies for the mapping of a disease gene is mentioned. Furthermore, the term linkage disequilibrium is introduced. Finally, several procedures used in current linkage analyses are briefly mentioned, with the aim of identifying the disease gene. The importance of genetic studies of disease families with many members, preferably from isolated surroundings to favor homogeneity, is stressed. However, such analyses can be performed only as a consequence of a close cooperation between clinicians and research scientists.

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