Dr. Hill is currently at the Clinical Neurophysiology Laboratory, Auckland Public Hospital, Auckland, New Zealand.
Photosensitive Epilepsy Studied by Functional Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy
Article first published online: 2 AUG 2005
Volume 40, Issue Supplement s4, pages 3–7, April 1999
How to Cite
Chiappa, K. H., Hill, R. A., Huang-Hellinger, F. and Jenkins, B. G. (1999), Photosensitive Epilepsy Studied by Functional Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy. Epilepsia, 40: 3–7. doi: 10.1111/j.1528-1157.1999.tb00899.x
- Issue published online: 2 AUG 2005
- Article first published online: 2 AUG 2005
- Functional MRI;
- MR spectroscopy;
- Generalized epilepsy;
Purpose: To study metabolic and hemodynamic correlates of photic stimulation-triggered discharges.
Methods: Simultaneous EEG, functional MRI (fMRI) and magnetic resonance spectroscopy (MRS) were performed in nine patients with photosensitive epilepsy and in 12 normal subjects.
Results: Prominent visual cortex activation was seen in all normal subjects and patients, and no fMRI-registered hemodynamic abnormalities were correlated with the brief photoparoxysmal spike-wave activity evoked in the photosensitive patients. However, irrespective of the presence of a spike-wave response to the photic stimulation, the photosensitive patients showed four findings not seen in the normal subjects: (a) slightly, but significantly, elevated lactate levels in the occipital cortex in the resting state; (b) an increased area of visual cortical activation with photic stimulation; (c) simultaneous with the occipital cortex stimulus-induced increased fMRI signal, there were noncontiguous areas of signal attenuation most prominent in perirolandic regions; and (d) a marked decrement (undershoot) of fMRI signal intensity immediately after the photic stimulation in the occipital cortex and in the region of the posterior cingulate gyrus.
Conclusions: These findings suggest abnormal interictal metabolism and increased vascular reactivity in the photosensitive patients.