Apolipoprotein E Polymorphisms and the Risk of Nonlesional Temporal Lobe Epilepsy

Authors

  • Antonio Gambardella,

    Corresponding author
    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
    2. Institute of Experimental Medicine and Biotechnology, National Research Council Piano Lago di Mangone-Cosenza, Italy
      Address correspondence and reprint requests to Dr. A. Gambardella at Cattedra ed U.O. di Neurologia, Facolta di Medicina e Chirurgia, Via Tommaso Campanella, 88100 Catanzaro, Italy. E-mail: neurol.unicz@interbusinessit
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  • Umberto Aguglia,

    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
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  • Rita Cittadella,

    1. Institute of Experimental Medicine and Biotechnology, National Research Council Piano Lago di Mangone-Cosenza, Italy
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  • Nelide Romeo,

    1. Institute of Experimental Medicine and Biotechnology, National Research Council Piano Lago di Mangone-Cosenza, Italy
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  • Grazia Sibilia,

    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
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  • Emilio LePiane,

    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
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  • Demetrio Messina,

    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
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  • Ida Manna,

    1. Institute of Experimental Medicine and Biotechnology, National Research Council Piano Lago di Mangone-Cosenza, Italy
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  • Rosario L. Oliveri,

    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
    2. Institute of Experimental Medicine and Biotechnology, National Research Council Piano Lago di Mangone-Cosenza, Italy
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  • Mario Zappia,

    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
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  • Aldo Quattrone

    1. Institute of Neurology, School of Medicine of Catanzaro, Catanzaro, Italy
    2. Institute of Experimental Medicine and Biotechnology, National Research Council Piano Lago di Mangone-Cosenza, Italy
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  • Presented in part at the 52nd Annual Meeting of the American Epilepsy Society, San Diego, December 4–10, 1998, and published in abstract form in Epilepsia 1998;39:S146.

Address correspondence and reprint requests to Dr. A. Gambardella at Cattedra ed U.O. di Neurologia, Facolta di Medicina e Chirurgia, Via Tommaso Campanella, 88100 Catanzaro, Italy. E-mail: neurol.unicz@interbusinessit

Abstract

Summary: Purpose: To evaluate whether the inheritance of the apolipoprotein E (ApoE) ε4 allele is a risk factor for nonlesional temporal lobe epilepsy (TLE), and to determine whether the newly described -491 A/T ApoE polymorphism may independently affect the risk of nonlesional TLE.

Methods: The study group consisted of 63 patients (35 women and 28 men; age at onset of epilepsy, 30.6 ± 19.6 years; mean (±SD). All of them had received a diagnosis of nonlesional TLE after a detailed clinical, electroencephalographic, and brain magnetic resonance investigation. The ApoE polymorphisms were determined from blood samples by standard methods. The molecular study also was performed in 220 age- and sex-matched normal individuals.

Results: There were no differences between TLE patients and controls in either allelic or genotypic frequencies of the ApoE and -491 A/T polymorphisms. Moreover, no effect of ApoE or -491 A/T polymorphisms was found on the age at onset and severity of epilepsy.

Conclusions: The allelic and genotypic frequencies of ApoE polymorphisms in Italian patients with nonlesional TLE are comparable to control values, indicating that ApoE polymorphisms are not a significant genetic risk factor for the occurrence of nonlesional TLE.

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