Presented in part at the 52nd Annual Meeting of the American Epilepsy Society, San Diego, December 4–10, 1998, and published in abstract form in Epilepsia 1998;39:S146.
Apolipoprotein E Polymorphisms and the Risk of Nonlesional Temporal Lobe Epilepsy
Article first published online: 2 AUG 2005
Volume 40, Issue 12, pages 1804–1807, December 1999
How to Cite
Gambardella, A., Aguglia, U., Cittadella, R., Romeo, N., Sibilia, G., LePiane, E., Messina, D., Manna, I., Oliveri, R. L., Zappia, M. and Quattrone, A. (1999), Apolipoprotein E Polymorphisms and the Risk of Nonlesional Temporal Lobe Epilepsy. Epilepsia, 40: 1804–1807. doi: 10.1111/j.1528-1157.1999.tb01602.x
- Issue published online: 2 AUG 2005
- Article first published online: 2 AUG 2005
- Accepted June 8, 1999.
- Apolipoprotein E;
- Temporal lobe epilepsy
Summary: Purpose: To evaluate whether the inheritance of the apolipoprotein E (ApoE) ε4 allele is a risk factor for nonlesional temporal lobe epilepsy (TLE), and to determine whether the newly described -491 A/T ApoE polymorphism may independently affect the risk of nonlesional TLE.
Methods: The study group consisted of 63 patients (35 women and 28 men; age at onset of epilepsy, 30.6 ± 19.6 years; mean (±SD). All of them had received a diagnosis of nonlesional TLE after a detailed clinical, electroencephalographic, and brain magnetic resonance investigation. The ApoE polymorphisms were determined from blood samples by standard methods. The molecular study also was performed in 220 age- and sex-matched normal individuals.
Results: There were no differences between TLE patients and controls in either allelic or genotypic frequencies of the ApoE and -491 A/T polymorphisms. Moreover, no effect of ApoE or -491 A/T polymorphisms was found on the age at onset and severity of epilepsy.
Conclusions: The allelic and genotypic frequencies of ApoE polymorphisms in Italian patients with nonlesional TLE are comparable to control values, indicating that ApoE polymorphisms are not a significant genetic risk factor for the occurrence of nonlesional TLE.