• 1
    Webber MP, Hauser WA, Ottman R, Annegers JF. Fertility in persons with epilepsy. Epilepsia 1986;27:74652.
  • 2
    Morrell MJ. Sexual dysfunction in epilepsy. Epilepsia 1991;32 (suppl 6):S3846.
  • 3
    Morrell MJ, Sperling MR, Stecker M, Dichter MA. Sexual dysfunction in partial epilepsy: a deficit in physiological sexual arousal. Neurology 1994;44:2437.
  • 4
    Herzog AG. A hypothesis to integrate partial seizures of temporal lobe origin and reproductive disorders. Epilepsy Res 1989;3:1519.
  • 5
    Herzog AG. Disorders of reproduction and fertility. In: EngelJ, PedleyTA, eds. Epilepsy: a comprehensive textbook. Philadelphia : Lippincott-Raven, 1997:20139.
  • 6
    Cramer JA, Jones EE. Reproductive function in epilepsy. Epilepsia 1991;32(suppl 6):S1926.
  • 7
    Cummings LN, Giudice L, Morrell MJ. Ovulatory function in epilepsy. Epilepsia 1995; 36:3559.
  • 8
    Isojarvi JI, Laatikainen TJ, Pakarinen AJ, Juntunen KTS, Myllyla VV. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Eng J Med 1993;329:13838.
  • 9
    Renaud LP. Influence of amygdala stimulation on the activity of identified tuberinfundibular neurons in the rat hypothalamus. J Physiol 1976;260:23752.
  • 10
    Meo R, Bilo L, Nappi C, et al. Derangement of the hypothalamic GnRH pulse generator in women with epilepsy. Seizure 1993;2:24152.
  • 11
    Zolovick AJ. Effects of lesions and electrical stimulation of the amygdala on hypothalamic-hypophyseal-regulation. In: EleftheriouBE, ed. The neurobiology of the amygdala. New York : Plenum Press, 1972:64383.
  • 12
    Velasco ME, Taleisnik S. Effects of the interruption of amygdaloid and hippocampal afferents to the medial hypothalamus on gonadotropin release. J Endocrinol 1971;51:4155.
  • 13
    Schachter SC. Hormonal considerations in women with seizures. Arch Neurol 1988;45:126770.
  • 14
    Beastall GH, Cowan RA, Gray JM, Fogelman I. Hormone binding globulins and anticonvulsant therapy. Scott Med J 1985;30:1015.
  • 15
    Morrell MJ. Hormones and epilepsy through the lifetime. Epilepsia 1992;33(suppl 4):S4961.
  • 16
    Jones TH. Sodium valproate-induced menstrual disturbances in young women. Horm Res 1991;35:825.
  • 17
    Grant SM, Heel RC. Vigabatrin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control. Drugs 1991;41:889926.
  • 18
    Carson RC, Wilkinson M. Seizure-induced delay of puberty in female rats: effects of age, stress and opioid antagonists. J Endocrinol 1989;121:22938.
  • 19
    Sherwood NM. Estrous cycles after electrical stimulation of the brain in conscious rats: effect of current strength, estradiol benzoate and progesterone. Endocrinology 1977;100:1829.
  • 20
    Bhanot R, Wilkinson M. Repeated convulsions induce pseudopregnancy in the intact rat and inhibit steroid-mediated gonadotrophin secretion in the ovariectomized rat. J Endocrinol 1982;95:438.
  • 21
    Amado D, Verreschi IT, Berzaghi MP, Cavalheiro EA. Effects of intrahippocampal injection of kainic acid on estrous cycle in rats. Braz J Med Biol Res 1987;20:82932.
  • 22
    Amado D, Cavalheiro EA. Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy. Epilepsy Res 1998;32:26674.
  • 23
    Wise PM. Alterations in the proestrous pattern of median eminence LHRH, serum LH, FSH, estradiol and progesterone concentrations in middle-aged rats. Life Sci 1982;31:16573.
  • 24
    Clemens JA, Amenomori Y, Jenkins T, Meites J. Effects of hypothalamic stimulation, hormones and drugs on ovarian function in old female rats. Proc Soc Exp Biol Med 1969;132:5613.
  • 25
    Edwards HE. Burnham WM, MacLusky NJ. Focal and generalized seizures differentially affect reproductive physiology in the male rat. Epilepsia (in press).
  • 26
    Freeman ME. The neuroendocrine control of the ovarian cycle of the rat. In: KnobilE, NeillJ, eds. The physiology of reproduction. Vol 2. 2nd ed. New York : Raven Press, 1994:613709.
  • 27
    Racine RJ. Modification of seizure activity by electrical stimulation: II. Motor seizure. EEG Clin Neurophysiol 1972;32:28194.
  • 28
    Brawer JR, Schipper H, Naftolin F. Ovary-dependent degeneration of hypothalamic arcuate nucleus. Endocrinology 1980;107:27481.
  • 29
    Brawer JR, Sonnenschein C. Cytopathological effects of estradiol on the arcuate nucleus of the female rat: a possible mechanism for pituitary tumorigenesis. Am J Anat 1976;144:5764.
  • 30
    Yen SSC, Vela P, Rankin J. Inappropriate secretion of follicle stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab 1970;30:43542.
  • 31
    Finch CE. Neuroendocrine mechanisms and aging. Fed Proc 1979;38:17883.
  • 32
    Weiland NG, Wise PM. Aging progressively decreases the densities and alters the diurnal rhythms of alpha 1-adrenergic receptors in selected hypothalamic regions. Endocrinology 1990;126:23927.
  • 33
    Simard M, Brawer JR, Farookhi R. An intractable, ovary-independent impairment in hypothalamo-pituitary function in the estradiol-valerate-induced polycystic ovarian condition in the rat. Biol Reprod 1987;36:122937.
  • 34
    Lieberman ME, Maurer RA, Claude P, Wiklund J, Wertz N, Gorski J. Regulation of pituitary growth and prolactin gene expression by estrogen. Adv Exp Med Biol 1981;128:15163.
  • 35
    Maurer RA. Estrogen-induced prolactin and DNA synthesis in immature female rat pituitaries. Mol Cell Endocrinol 1979;13:291300.
  • 36
    Gunnet JW, Freeman ME. The mating-induced release of prolactin: a unique neuroendocrine response. Endocr Rev 1983;4:4460.
  • 37
    Copmann TL, Adams WC. Relationship of polycystic ovary induction to prolactin secretion: prevention of cyst formation by bromocriptine in the rat. Endocrinology 1981;108:10957.
  • 38
    Erickson GF, Magoffin DA, Dyer CA, Hofedits CH. The ovarian androgen producing cells: a review of structure/function relationships. Endocr Rev 1986;6:37199.
  • 39
    Franks S, Mason HD, Polson DW, Winston RML, Margara R, Reed ML. Mechanisms and management of ovulatory failure in women with polycystic ovary syndrome. Hum Reprod 1988;3:5314.
  • 40
    Franks S. The ubiquitous polycystic ovary. J Endocrinol 1991;129:3179.
  • 41
    Yen SSC. The polycystic ovary syndrome. Clin Endocrinol 1980;12:177208.
  • 42
    Daane TA, Parlow AF. Serum FSH and LH in constant-light induced persistent estrus: short-term and long-term studies. Endocrinology 1971;88:9649.
  • 43
    Naftolin F, Brown-Grant K, Corker CS. Plasma and pituitary luteinizing hormone and peripheral plasma oestradiol concentration in the normal oestrous cycle of the rat and after experimental manipulation of the cycle. J Endocrinol 1972;53:1724.
  • 44
    Mahajan DL. Polycystic ovarian disease: animal models. Endocrinol Metab Clin North Am 1988;17:70532.
  • 45
    Jones HM, Vernon MW, Rush ME. Systemic studies invalidate the neonatally androgenized rat as a model for polycystic ovary disease. Biol Reprod 1987;36:125365.
  • 46
    Herzog AG, Russell V, Vaitukaitis JL, et al. Neuroendocrine dysfunction in temporal lobe epilepsy. Arch Neurol 1982;39:1335.
  • 47
    Edwards HE, Burnham WM, MacLusky NJ. Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures. Brain Res (in press).
  • 48
    Edwards HE, Burnham WM, Mendonca A, Bowlby DA, MacLusky NJ. Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats. Brain Res (in press).