Multimodal MR Imaging: Functional, Diffusion Tensor, and Chemical Shift Imaging in a Patient with Localization-Related Epilepsy
Article first published online: 2 AUG 2005
Volume 40, Issue 10, pages 1459–1462, October 1999
How to Cite
Krakow, K., Wieshmann, U. C., Woermann, F. G., Symms, M. R., McLean, M. A., Lemieux, L., Allen, P. J., Barker, G. J., Fish, D. R. and Duncan, J. S. (1999), Multimodal MR Imaging: Functional, Diffusion Tensor, and Chemical Shift Imaging in a Patient with Localization-Related Epilepsy. Epilepsia, 40: 1459–1462. doi: 10.1111/j.1528-1157.1999.tb02021.x
- Issue published online: 2 AUG 2005
- Article first published online: 2 AUG 2005
- Accepted April 6, 1999.
- Functional MRI;
- Diffusion tensor imaging;
- Chemical shift imaging;
- Localization-related epilepsy;
- Malformation of cortical development (MCD)
Summary: Purpose: To demonstrate the integration of complementary functional and structural data acquired with magnetic resonance imaging (MRI) in a patient with localization-related epilepsy.
Methods: We studied a patient with partial and secondarily generalized seizures and a hemiparesis due to a malformation of cortical development (MCD) in the right hemisphere by using EEG-triggered functional MRI (fMRI), diffusion tensor imaging (DTI), and chemical shift imaging (CSI).
Results: fMRI revealed significant changes in regional blood oxygenation associated with interictal epileptiform discharges within the MCD. DTI showed a heterogeneous microstructure of the MCD with reduced fractional anisotropy, a high mean diffusivity, and displacement of myelinated tracts. CSI demonstrated low N-acetyl aspartate (NAA) concentrations in parts of the MCD.
Conclusions: The applied MR methods described functional, microstructural, and biochemical characteristics of the epileptogenic tissue that cannot be obtained with other noninvasive means and thus improve the understanding of the pathophysiology of epilepsy.