You have full text access to this OnlineOpen article
A Ketogenic Diet Increases the Resistance to Pentylenetetrazole-Induced Seizures in the Rat
Article first published online: 2 AUG 2005
DOI: 10.1111/j.1528-1157.1999.tb02066.x
Additional Information
How to Cite
Bough, K. J. and Eagles, D. A. (1999), A Ketogenic Diet Increases the Resistance to Pentylenetetrazole-Induced Seizures in the Rat. Epilepsia, 40: 138–143. doi: 10.1111/j.1528-1157.1999.tb02066.x
Publication History
- Issue published online: 2 AUG 2005
- Article first published online: 2 AUG 2005
- Accepted August 17, 1998.
References
- 1. Fasting as a method for treating epilepsy. Med Rec 1921;99:1037–9.
- 2, , . Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 1996; 37 (suppl 2):S81–95.
- 3. The effects of ketonemia on the course of epilepsy. Mayo Clin Proc 1921;2:307–8.
- 4, . Eight years' experience with the ketogenic diet in the treatment of epilepsy. JAMA 1930;95:707–9.
- 5
- 6Dietary treatment of epilepsy. In: Livingston S. Comprehensive management of epilepsy in infancy, childhood and adolescence. Springfield , IL : Charles C Thomas, 1972; 378–405.
- 7, , , , . Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 1992;33:1132–6.Direct Link:
- 8, , Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev Med Child Neural 1989;31:152–60.Direct Link:
- 9, , , . Effects of ketosis on glucose flux in children and adults. Am J Physiol 1983; 245 (Endocrinol Metab 8): E373–8.
- 10, , . Starvation and seizures: observations on the electroconvulsive threshold and cerebral metabolism of the starved adult rat. Arch Neurol 1975;32:755–60.
- 11, . An animal model for the ketogenic diet. Epilepsia 1974;15:211–27.Direct Link:
- 12. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 1976;10:536–40.
- 13, , . The epilepsy diet treatment: an introduction to the ketogenic diet. New York : Demos, 1994.
- 14, , , . Diet-induced ketosis does not cause cerebral acidosis. Epilepsia 1996;37:258–61.
- 15, . A timed intravenous pentylenetetrazole infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. J Pharmacol Methods 1985;13:135–46.
- 16. The laboratory rat. Vol I. New York : Academic Press, 1979.
- 17, Proconvulsant effect of morphine on seizures induced by pentylenetetrazole in the rat. Eur J Pharm 1984;105:179–84.
- 18, . Statistical analysis with missing data. New York : Academic Press, 1979.
- 19, . Using multivariate statistics. 2nd ed. New York : John Wiley, 1987.
- 20, . The ketogenic diet revisited: back to the future. Epilepsia 1997;38:743–9.Direct Link:
- 21, , , et al. Antiketogenic effect of glucose per se in vivo in man and in vitro in isolated rat liver cells. Metabolism 1986;35:608–13.
- 22, , Metabolic interactions of glucose, lactate, and β-hydroxybutyrate in rat brain slices. Am J Physiol 1969;217:784–92.
- 23, , , Chronic ketosis and cerebral metabolism. Ann Neurol 1978;3:331–7.Direct Link:
- 24. Ketone body metabolism during development. Fed Proc 1985;44:2342–6.
- 25, , , . Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia 1997;38:750–8.Direct Link:
- 26, , , , Effect of ketogenic diet on convulsive threshold and brain monoamine levels in young mice. No To Hattatsu 1984;16:196–204.
- 27, , . Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J 1971;122:13–8.
- 28. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32:281–94.
- 29, , , et al. Pentylenetetrazoleinduced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res 1996;26:105–13.
- 30, , . Mechanism of anticonvulsant action of the ketogenic diet. Am J Dis Child 1964;107:593–604.
- 31, . Anticonvulsant properties of the ketogenic diet in mice. J Pharmacol Exp Ther 1972;180:231–8.

1528-1167/asset/olbannerleft.gif?v=1&s=bae5cfdb8dec65198cd267c78826e3fef2ef0ede)
1528-1167/asset/cover.gif?v=1&s=59b70f784d68dff627ce355992d93281b96ae119)