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Dietary Fat, Ketosis, and Seizure Resistance in Rats on the Ketogenic Diet
Article first published online: 2 AUG 2005
DOI: 10.1111/j.1528-1157.2000.tb00115.x
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How to Cite
Likhodii, S. S., Musa, K., Mendonca, A., Dell, C., Burnham, W. M. and Cunnane, S. C. (2000), Dietary Fat, Ketosis, and Seizure Resistance in Rats on the Ketogenic Diet. Epilepsia, 41: 1400–1410. doi: 10.1111/j.1528-1157.2000.tb00115.x
Publication History
- Issue published online: 2 AUG 2005
- Article first published online: 2 AUG 2005
- Accepted July 5, 2000
REFERENCES
- 1, Comprehensive management of epilepsy in infancy, childhood, and adolescence. Springfield , IL : Charles C Thomas, 1972.
- 2, , , The epilepsy diet treatment: an introduction to the ketogenic diet. New York : Demos Vermande, 1996.
- 3, , Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer. J Am Diet Assoc 1995;95:693–7.
- 4, [Diagnosis and therapy of mitochondriopathies.] [German] Wien Klin Wochenschr 1997;109:93–9.
- 5, , , , , , Infantile phosphofructokinase deficiency with arthrogryposis: clinical benefit of a ketogenic diet. J Pediatr 1997;131:932–4.
- 6, , , et al. Defective glucose transport across brain tissue barriers: a newly recognized neurological syndrome. Neurochem Res 1999;24:587–94.
- 7, , The ketogenic diet: a practical guide for caregivers. J Am Diet Assoc 1998;98:316–21.
- 8, Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 1976;10:536–40.
- 9, , A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia 1999;40:138–43.Direct Link:
- 10, Medium-chain triglyceride diet in intractable seizure disorders. Neurology 1985;35:237–8.
- 11, , , , Ketogenic diets in the treatment of epilepsy: short-term clinical effects. Dev Med Child Neurol 1989;31:145–51.Direct Link:
- 12, , , Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev Med Child Neurol 1989;31:152–60.Direct Link:
- 13, , , Corn oil ketogenic diet for children with intractable seizures. J Child Neurol 1988;3:21–4.
- 14, , , , , Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long-chain polyunsaturated fatty acids. Pediatr Res 1995;38:262–6.
- 15, , , , , , Age- and dietary-related distributions of hepatic arachidonic and docosahexaenoic acid in early infancy. Pediatr Res 1995;38:361–5.
- 16, , , Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. Am J Physiol 1995;269:R80–6.
- 17, , An animal model for the ketogenic diet. Epilepsia 1974;15:211–27.Direct Link:
- 18, , , Effects of ketogenic diet on electroconvulsive threshold and brain contents of adenosine nucleotides. Brain Dev 1983;5:375–80.
- 19, , , , Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia 1997;38:750–8.Direct Link:
- 20, , , Mechanism of anticonvulsant action of ketogenic diet. Am J Dis Child 1964;107:593–604.
- 21, , Anticonvulsant properties of the ketogenic diet in mice. J Pharmacol Exp Ther 1972;180:231–8.
- 22, , , , Fasting and ketogenic diet effects on audiogenic seizures: susceptibility of magnesium deficient rats. Pharmacol Biochem Behav 1983;18:683–7.
- 23, , , , , [Effect of ketogenic diet on the convulsive threshold and brain amino acid and monoamine levels in young mice.] [Japanese] No to Hattatsu [Brain Dev] 1984;16:196–204.
- 24, , AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993;123:1939–51.
- 25US Department of Agriculture, Agricultural Research Service. USDA Nutrient Database for Standard Reference. Release 13, 1999. Nutrient Data Laboratory Home Page, http://www.nal.usda.govfnicfoodcomp.
- 26, , , Enzymatic determination of D(–)-β-hydroxybutyric acid and acetoacetic acid in blood. Biochem J 1962;82:90–6.
- 27, , , , , Antiepileptic drug development. II. Anticonvulsant drug screening. Epilepsia 1978;19:409–28.Direct Link:
- 28, , , , , Metabolic effects induced by long-term feeding of medium-chain triglycerides in the rat. Metabolism 1987;36:807–14.
- 29, , Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol Rev 1980;60:143–87.
- 30, , , , , , Control of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the foetal/neonatal transition, suckling and weaning in the rat. Eur J Biochem 1991;195:449–54.
- 31, Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochem J 1999;338:569–82.
- 32, , , , , , Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic 3-hydroxy-3-methylglutaryl-CoA cycle in central nervous system of suckling rat. Biochem J 1998;329:373–81.
- 33, , , et al. Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene: its role in the control of ketogenesis. Biochem J 1992;283:261–64.
- 34, , Induction processes in blood-brain transfer of ketone bodies during starvation. Am J Physiol 1975;229:1165–9.
- 35, , , , Astrocyte foot processes and blood-brain transport. In: LeeTJF, PearceWJ, eds. XVIIIth International Symposium on Cerebral Blood Flow and Metabolism, Williamsburg, Va, 1997: 40.
- 36, , , Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study. Dev Brain Res 1999;113:47–54.
- 37
- 38, Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia. Diabetes Metab 1997;23:18–29.
- 39, , , Chronic ketosis and cerebral metabolism. Ann Neurol 1978;3:331–7.Direct Link:
- 40, Blood-brain barrier, ion homeostasis and epilepsy: possible implications towards the understanding of ketogenic diet mechanisms. Epilepsy Res 1999;37:223–32.
- 41, Starvation. Trans Am Clin Climatol Assoc 1982;94:1–21.
- 42, , , , Thermic effect of medium-chain and long-chain triglycerides in man. Am J Clin Nutr 1986;44:630–4.
- 43, , , A ketogenic diet exacerbates kainate-induced seizures in the rat. Soc Neurosc Abstr 1998;24:1208.
- 44, , , et al. The MCT ketogenic diet: effects on animal seizure models. Exp Neurol 2000;161:696–703.
- 45, , Modification of electroshock and pentylenetetrazol seizure patterns in rats after precollicular transections. Exp Neurol 1986;93:546–56.
- 46, , , Evening primrose monograph. In: NewallCA, AndersonLA, PhillipsonJD, eds. Herbal medicines: a guide for health-care professionals. London : Pharmaceutical Press, 1997:110–3.
- 47, , , A ketogenic diet markedly exacerbates seizure severity but elevates seizure threshold in the same animals. Epilepsia 1998;39(suppl 6):45.
- 48, , Seizures, brain damage and brain development. Brain Dev 1994;16:279–95.
- 49, Reversible disability associated with epilepsy. Brain Dev 1999;21:82–5.
- 50, , Utilization of carbon from dietary polyunsaturates for brain cholesterol synthesis during early postnatal development in the rat: a 13C NMR study, Magn Reson Med 1995; 34:803–13.Direct Link:
- 51, , , , , Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain, J Neurochem 1998;71:2151–8.
- 52, , , Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol 1994;254:193–8.
- 53, , , , , , Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc Natl Acad Sci USA 1996;93:12559–63.
- 54, , , , Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol 1998;341: 145–52.

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