• 1
    Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clin Proc 1921:3078.
  • 2
    Mcldrum BS. Identification and preclinical testing of novel anti-epileptic compounds. Epilepsia 1997;38(suppl 9):S715.
  • 3
    Schwartzkroin PA, Rho JM. The ketogenic diet: mechanisms and models. Epilepsy Res 1999;37(3):169.
  • 4
    Stafstrom CE. Animal models of the ketogenic diet: what have we learned, what can we learn Epilepsy Res 1999;37:24159.
  • 5
    Hughes PE, Alexi P, Walton M, et al. Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system. Prog Neurobiol 1999;57:42150.
  • 6
    Lowenstein DH. Recent advances related to basic mechanisms of epileptogenesis. Epilepsy Res Suppl 1996;11:4560.
  • 7
    Nordli DR Jr, De Vivo DC. The ketogenic diet revisited: back to the future. Epilepsia 1997;38:7439.
  • 8
    Stafstrom CE, Wang C, Jensen FE. Electrophysiological observations in hippocampal slices from rats treated with the ketogenic diet. Dev Neurosci 1999;21:3939.
  • 9
    Muller-Schwarze AB, Tandon P, Liu Z, Yang Y, Holmes GL, Stafstrom CE. Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model. Neuroreport 1999;10:151722.
  • 10
    Fueta Y, Matsuoka S, Mita T. Crossbreeding analysis of the mouse epilepsy. Sangyo Ika Daigaku Zasshi 1986;20:41724.
  • 11
    Frankel WN, Valenzuela A, Lutz CM, Johnson EW, Dietrich WF, Coffin JM. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 1995;6:8308.
  • 12
    Todorova MT, Burwell TJ, Seyfried TN. Environmental risk factors for multifactorial epilepsy in EL mice. Epilepsia 1999;40:1697707.
  • 13
    Ishida N, Kasamo K, Nakamoto Y, Suzuki J. Epileptic seizure of El mouse initiates at the parietal cortex: depth EEG observation in freely moving condition using buffer amplifier. Brain Res 1993;608:527.
  • 14
    Seyfried TN, Todorova MT. Experimental models of epilepsy. In: KotagalP, LudersHO, eds. The epilepsies: ethiologies and prevention. San Diego : Academic Press, 1999:52742.
  • 15
    Suzuki J, Matsushita M, Nakamoto Y. Histopathological alterations in the hippocampus of an EL mouse. Folia Psychiatr Jpn 1983;37:3623.
  • 16
    Brigande JV, Wieraszko A, Albert MD, Balkema GW, Seyfried TN. Biochemical correlates of epilepsy in the EL mouse: analysis of glial fibrillary acidic protein and gangliosides. J Neurochem 1992;58:75260.
  • 17
    Seyfried TN, Brigande JV, Flavin HJ, Frankel WN, Rise ML, Wieraszko A. Genetic and biochemical correlates of epilepsy in the EL mouse. Neurosciences 1992;18(suppl 2):920.
  • 18
    Todorova M, Tandon P, Madore RA, Stafstrom CE, Seyfried TN. Ketogenic diet induces ketonemia and inhibits seizures in epileptic EL mice. Epilepsia 1998;39(suppl 6):38.
  • 19
    Hori A, Tandon P, Holmes GL, Stafstrom CE. Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia 1997;38:7508.
  • 20
    Rho MJ, Kim DW, Robbins CA, Anderson GD, Schwartzkroin PA. Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet. Epilepsy Res 1999;37:23340.
  • 21
    Hayes JM, Balkema GW. Elevated dark-adapted thresholds in hypopigmented mice measured with a water maze screening apparatus. Behav Genet 1993;23:395403.
  • 22
    Utsumi K, Yoshida K, Maeda T, Mori M, Tatsumi H. Small scale efficient reproduction of EL mice. Jikken Dobutsu 1978;27:3059.
  • 23
    Freeman JM, Vining EP, Pillas DJ, Pyzik PL, Casey JC, Kelly LM. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998;102:135863.
  • 24
    Vining EP, Freeman JM, Ballaban-Gil K, et al. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998;55:14337.
  • 25
    Vining EPG. Clinical efficacy of the ketogenic diet. Epilepsy Res 1999;37:18190.
  • 26
    Nehlig A, Pereira de Vasconcelos A. Glucose and ketone body utilization by the brain of neonatal rats. Prog Neurobiol 1993;40:163221.
  • 27
    Bough KJ, Valiyil R, Han FT, Eagles DA. Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res 1999;35:218.
  • 28
    Bough KJ, Eagles DA. A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia 1999;40:13843.
  • 29
    Scotti AL, Bollag O, Nitsch C. Seizure patterns of Mongolian gerbils subjected to a prolonged weekly test schedule: evidence for a kindling-like phenomenon in the adult population. Epilepsia 1998;39:56776.
  • 30
    Kinsman SL, Vining EP, Quaskey SA, Mellits D, Freeman JM. Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 1992;33:11326.
  • 31
    Nigro MA, Ventimiglia J, Selcen D, Beierwaltes P. Seizure frequency, behavioral, and performance effects of the ketogenic diet. Ann Neurology 1995;38:54950.
  • 32
    Wing RR, Vazquez JA, Ryan CM. Cognitive effects of ketogenic weight-reducing diets. Int J Obes Relat Metab Disord 1995;19:8116.
  • 33
    Deleted in proof.
  • 34
    Nehlig A. Age-dependent pathways of brain energy metabolism: the suckling rat, a natural model of the ketogenic diet. Epilepsy Res 1999;37:21121.
  • 35
    Schwarzkroin PA. Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet. Epilepsy Res 1999;37:17180.
  • 36
    DeVivo DC, Leckie MP, Ferrendelli JS, McDougal DB Jr. Chronic ketosis and cerebral metabolism. Ann Neurol 1978;3:3317.
  • 37
    McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 1980;49:395420.
  • 38
    Huttenlocher PR. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 1976;10:53640.
  • 39
    Dodson WE, Prensky AL, DeVivo DC, Goldring S, Dodge PR. Management of seizure disorders: selected aspects: part II. J Pediatr 1976;89:695703.
  • 40
    Freeman JM, Vinning EPG. Seizures decrease rapidly after fasting: preliminary studies of the ketogenic diet. Arch Pediatr Adolesc Med 1999;153:9469.
  • 41
    Swink TD, Vinning EP, Freeman JM. The ketogenic diet: 1997. Adv Pediatr 1997;44:297329.
  • 42
    Al-Mudallal AS, Levin BE, Lust WD, Harik SI. Effects of unbalanced diets on cerebral glucose metabolism in the adult rat. Neurology 1995;45:22615.
  • 43
    Dekaban AS. Plasma lipids in epileptic children treated with the high fat diet. Arch Neurol 1966;15:17784.
  • 44
    Schwartz RM, Boyes S, Aynsley-Green A. Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev Med Child Neurol 1989;31:15260.
  • 45
    Sibson NR, Shen J, Mason GF, Rothman DL, Behar KL, Shulman RG. Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronal activity, Dev Neurosci 1998;20:32130.
  • 46
    Kawasaki H, Itoh M, Nakahara T, Fukahori M, Akazawa K. [3H]MK-801 binding to forebrain of EL (epileptic) and non-epileptic strains of mice. Epilepsy Res 1991;8:2205.
  • 47
    Daikhin Y, Yudkoff M. Ketone bodies and brain glutamate and GABA metabolism. Dev Neurosci 1998;20:35864.
  • 48
    Fueta Y, Kawano H, Ono T, Mita T, Fukata K, Ohno K. Regional differences in hippocampal excitability manifested by paired-pulse stimulation of genetically epileptic EL mice. Brain Res 1998;779:3248.
  • 49
    Flavin HJ, Seyfried TN. Enhanced aspartate release related to epilepsy in (EL) mice. J Neurochem 1994;63:5925.