• 1
    Theodore WH, Newmark ME, Sato S, et al. [18F]fluorodeoxyglucose positron emission tomography in refractory complex partial seizures. Ann Neurol 1983;14:42937.
  • 2
    Cavazos JE, Das I, Sutula TP. Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures. J Neurosci 1994;14:310621.
  • 3
    Cavalheiro EA, Leite JP, Bortolotto ZA, Turski WA, Ikonomidou C, Turski L. Long term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia 1991;32:77882.
  • 4
    Cendes F, Andermann F, Gloor P, et al. Atrophy of mesial structures in patients with temporal lobe epilepsy: cause or consequences of repeated seizures Ann Neurol 1993;34:795801.
  • 5
    Kuzniecky RI, Burgard S, Bilir E, et al. Qualitative MRI segmentation in mesial temporal sclerosis: clinical correlations. Epilepsia 1996;37:4339.
  • 6
    Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P, Pitkänen A. Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy. Neurology 1998;50:137782.
  • 7
    Tasch E, Cendes F, Li LM, Dubeau F, Andermann F, Arnold DL. Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy. Ann Neurol 1999;45:56876.
  • 8
    Leiderman DB, Albert P, Balish M, Bromfield E, Theodore WH. The dynamics of metabolic change following seizures as measured by positron emission tomography with fluodeoxyglucose F 18. Arch Neurol 1994;51:9326.
  • 9
    Breier JI, Mullani NA, Thomas AB, et al. Effects of duration of epilepsy on the uncoupling of metabolism and blood flow in complex partial seizures. Neurology 1997;484:104753.
  • 10
    Theodore WH, Bhatia S, Hatta J, et al. Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures. Neurology 1999;52:1326.
  • 11
    Gaillard WD, Zeffiro T, Fazilat S, DeCarli C, Theodore WH. Effect of valproate on cerebral metabolism and blood flow: an 18F 2-deoxyglucose and 15O water positron emission tomography study, Epilepsia 1996;37:51521.
  • 12
    Babb TL, Lieb JP, Brown WJ, Pretorius J, Crandall PH. Distribution of pyramidal cell density and hyperexcitability in the epileptic human hippocampal formation. Epilepsia 1984;25:7218.
  • 13
    Mouritzen Dam A. Hippocampal neuron loss in epilepsy and after experimental seizures. Acta Neurol Scand 1982;66:60142.
  • 14
    Mathern GW, Babb TL, Leite JP, Pretorius JK, Yeoman KM, Kuhlman PA. The pathogenic and progressive features of chronic human hippocampal epilepsy. Epilepsy Res 1996;26:15161.
  • 15
    Gaillard WD, Conry JA, Weinstein S, et al. Metabolic abnormalities in children with recent onset partial epilepsy determined by FDG-PET. Epilepsia 1999;40(suppl 2):2201.