• 1
    McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev 1999;20:279307.
  • 2
    Henderson VW. The epidemiology of estrogen replacement therapy and Alzheimer's disease. Neurology 1997;48:S2735.
  • 3
    Henderson VW. Estrogen, cognition, and a woman's risk of Alzheimer's disease. Am J Med 1997;103:11S18S.
  • 4
    Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Shimohama S. Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death. J Neurosci Res 1998;54:70719.
  • 5
    Simpkins JW, Green PS, Gridley KE, Singh M, de Fiebre NC, Rajakumar G. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. Am J Med 1997;103:19S25S.
  • 6
    Babb TL, Brown WJ. Pathological findings in epilepsy. In: EngelJJr, ed. Surgical treatment of the epilepsies. New York : Raven Press, 1987:51140.
  • 7
    Engel J Jr, Williamson PD, Wieser H-G. Mesial temporal lobe epilepsy. In: EngelJJr, PedleyTA, eds. Epilepsy: a comprehensive textbook. Philadelphia : Lippincott-Raven Publishers, 1997:241726.
  • 8
    Sloviter RS. The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol 1994;35:64054.
  • 9
    Sutula T, Cascino G, Cavazos J, Parada I, Ramirez L. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 1989;26:32130.
  • 10
    Mathern GW, Babb TL, Armstrong DL. Hippocampal sclerosis. In: EngelJJr, PedleyTA, eds. Epilepsy: a comprehensive textbook. Philadelphia : Lippincott-Raven, 1997:13355.
  • 11
    Morrell MJ. Hormones, reproductive health, and epilepsy. In: WyllieE, ed. The treatment of epilepsy: principles and practice. Baltimore : Williams & Wilkins, 1997:17987.
  • 12
    Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 1986;43:3416.
  • 13
    Herzog AG. Clomiphene therapy in epileptic women with menstrual disorders. Neurology 1988;38:4324.
  • 14
    Sloviter RS. Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies. Brain Res Bull 1983;10:67597.
  • 15
    Sperber EF, Sutula TP, Moshé SL. Synaptic sprouting following kindled seizures. Epilepsia 1990;31:633.
  • 16
    Nadler JV, Perry BW, Cotman CW. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature 1978;271:6767.
  • 17
    Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 1985;14:375403.
  • 18
    Nadler JV. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 1981;29:203142. Minireview.
  • 19
    Nadler JV, Okazaki MM, Gruenthal M, Ault B, Armstrong DR. Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs. Adv Exp Med Biol 1986;203:67386.
  • 20
    Sperk G, Lassman H, Baran H, Seitelberger F, Hornykiewicz O. Kainic acid-induced seizures: dose relationship of behavioural, neurochemical and histopathological changes. Brain Res 1985;338:28995.
  • 21
    Azcoitia I, Sierra A, Garcia-Segura LM. Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus. NeuroReport 1998;9:30759.
  • 22
    Gallyas F, Wolff JR, Bottcher H, Zaborszky L. A reliable and sensitive method to localize terminal degeneration and lysosomes in the central nervous system. Stain Technol 1980;55:299306.
  • 23
    Lundberg PO. Catamenial epilepsy: a review. Cephalgia 1997;17:425.
  • 24
    Buterbaugh G, Hudson GM. Estradiol replacement to female rats facilitates dorsal hippocampal but not ventral hippocampal kindled seizure acquisition. Ann Neurol 1991;111:5564.
  • 25
    Hom AC, Buterbaugh GG. Estrogen alters the acquisition of seizures kindled by repeated amygdala stimulations or pentylenetetrazol administration in ovariectomized female rats. Epilepsia 1986;27:1038.
  • 26
    Nicoletti F, Speciale C, Sortino MA, et al. Comparative effects of estradiol benzoate, the antiestrogen clomiphene citrate, and the progestin medroxyprogesterone acetate on kainic acid-induced seizures in male and female rats. Epilepsia 1985;26:2527.
  • 27
    Velíšek L, Velíšková J, Moshé SL, Vathy I. Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility. Brain Res 1998;796:24756.
  • 28
    Velíšek L, Velíšková J, Etgen AM, Stanton PK, Moshé SL. Region-specific modulation of limbic seizure susceptibility by ovarian steroids. Brain Res 1999;842:1328.
  • 29
    Jacono JJ, Robertson JMD. The effects of estrogen, progesterone, and ionized calcium on seizures during the menstrual cycle of epileptic women. Epilepsia 1987;28:5717.
  • 30
    Schwartz-Giblin S, Korotzer A, Pfaff DW. Steroid hormone effects on picrotoxin-induced seizures in female and male rats. Brain Res 1989;476:2407.
  • 31
    Simpkins JW, Rajakumar G, Zhang YQ, et al. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 1997;87:72430.
  • 32
    Zhang YQ, Shi J, Rajakumar G, Day AL, Simpkins JW. Effects of gender and estradiol treatment on focal brain ischemia. Brain Res 1998;784:3214.
  • 33
    Wang Q, Santizo R, Baughman VL, Pelligrino DA, Iadecola C. Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats. Stroke 1999;30:6307.
  • 34
    Behl C, Skutella T, Lezoualch F, et al. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 1997;51:53541.
  • 35
    Weaver CE Jr, Park-Chung M, Gibbs TT, Farb DH. 17-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res 1997;761:33841.
  • 36
    Mermelstein PG, Becker JB, Surmeier DJ. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. Neurosci 1996;16:595604.
  • 37
    Hayashi T, Ishikawa T, Yamada K, et al. Biphasic effect of estrogen on neuronal constitutive nitric oxide synthase via Ca2+-calmodulin dependent mechanism. Biochem Biophys Res Commun 1994;203:10139.
  • 38
    McEwen BS. Non-genomic and genomic effects of steroids on neural activity. Trends Pharmacol Sci 1991;12:1414.
  • 39
    Darwish H, Krisinger J, Furlow JD, Smith C, Murdoch FE, De-Luca HF. An estrogen-responsive element mediates the transcriptional regulation of calbindin D-9K gene in rat uterus. J Biol Chem 1991;266:5518.
  • 40
    Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 1999;19:638593.
  • 41
    Pike CJ. Estrogen modulates neuronal Bcl-xL expression and β-amyloid-induced apoptosis: relevance to Alzheimer's disease. J Neurochem 1999;72:155263.
  • 42
    Olazabal UE, Pfaff DW, Mobbs CV. Sex differences in the regulation of heat shock protein 70 kDa and 90 kDa in the rat ventromedial hypothalamus by estrogen. Brain Res 1992;596:3114.
  • 43
    Toran-Allerand CD, Singh M, Setalo G Jr. Novel mechanisms of estrogen action in the brain: new players in an old story. Front Neuroendocrinol 1999;20:97121.
  • 44
    Sohrabji F, Miranda RC, Toran-Allerand CD. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc Natl Acad Sci USA 1995;92:111104.
  • 45
    Sohrabji F, Greene LA, Miranda RC, Toran-Allerand CD. Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. J Neurobiol 1994;25:97488.
  • 46
    Tandon P, Yang Y, Das K, Holmes GL, Stafstrom CE. Neuroprotective effects of brain-derived neurotrophic factor in seizures during development. Neuroscience 1999;91:293303.
  • 47
    Van der Zee CEEM, Rashid K, Le K, et al. Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats. J Neurosci 1995;15:531623.
  • 48
    Azcoitia I, Sierra A, Garcia-Segura LM. Neuroprotective effects of estradiol in the adult rat hippocampus: interaction with insulin-like growth factor-I signalling. J Neurosci Res 1999;58:81522.