• 1
    Shank, RP, Gardocki, JF, Vaught, JL, et al. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 1994;35:45060.
  • 2
    McLean, MJ, Macdonald, RL. Multiple actions of phenytoin on mouse spinal cord neurons in cell culture. J Pharmacol Exp Ther 1983;227:77989.
  • 3
    Courtney, KR, Etter, EG. Modulated anticonvulsant block of sodium channels in nerve and muscle. Eur J Pharmacol 1983;88:19.
  • 4
    McLean, MJ, Macdonald, RL. Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 1986;238:72739.
  • 5
    Cheng, H, Kamp, D, Harris, E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res 1992;13:10713.
  • 6
    Schwarz, JR, Grigat, G. Phenytoin and carbamazepine: potential-and frequency-dependent block of Na+ currents in mammalian myelinated nerve fibers. Epilepsia 1989;30:28694.
  • 7
    Ragsdale, DS, Scheuer, T, Catterall, WA. Frequency- and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line. Mol Pharmacol 1991;40:75665.
  • 8
    Rogawski, MA, Porter, RJ. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 1990;42:22386.
  • 9
    Lang, DG, Wang, CM, Coper, BR. Lamotrigine, phenytoin and carbamazepine interactions in the sodium current present in N4TGI mouse neuroblastoma cells. J Pharmacol Exp Ther 1993;266:82939.
  • 10
    Coulter, DA, Sombati, S, DeLorenzo, RJ. Selective effects of TPM on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons. Epilepsia 1993;34(suppl 2):123.
  • 11
    DeLorenzo, RJ, Sombati, S, Coulter, DA. Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons. Epilepsia 2000;41(suppl 1):S404.
    Direct Link:
  • 12
    Wamil, AW, McLean, MJ. Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture. Epilepsy Res 1994;17:111.
  • 13
    Shank, RP, Gardocki, JF, Streeter, AJ, Maryanoff, BE. An overview of the preclinical aspects of topiramate: pharmacology, pharmaco-kinetics and mechanism of action. Epilepsia 2000;41(suppl 1):S39.
  • 14
    Zona, C, Ciotti, MT, Avoli, M, Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells in culture. Neurosci Lett 1997;231:1236.