• 1
    Kaneko, S, Kondo, T. Antiepileptic agents and birth defects. Incidence, mechanisms and prevention. CNS Drugs 1995;3:4155.
  • 2
    Ogawa, Y, Fukushi, A, Nomura, Y, et al. Complications of pregnancy, labor and delivery in women with epilepsy. In: Sato, T, Shinagawa, S. eds. Antiepileptic drugs and pregnancy. Amsterdam : Excerpta Medica, 1984:8797.
  • 3
    Kaneko, S. Antiepileptic drug therapy and reproductive consequence: Functional and morphologic effects. Reprod Toxicol 1991;5:179198.
  • 4
    Nau, H, Rating, D, Koch, S, Hauser, I, Helge, H. Valproic acid and its metabolites: Placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in nconates of epileptic mothers. J Pharmacol Exp Ther 1981a;291:768777.
  • 5
    Kojima, S, Ogura, H, Yokoyama, M, Ookawa, S. The effect of di-azepam on neonatal neurobehavioral response. Acta Obstet Gynecol Jpn 1985;37:278490.
  • 6
    de Vinsky, O, Yerby, MS. Women with epilepsy. Neurol Clin 1994;16:479496.
  • 7
    Mattson, RH, Cramer, JA, Darney, PD, Naftolin, F. Use of oral contraceptives by women with epilepsy. JAMA 1986;256:238240.
  • 8
    Kaneko, S. Responses to antiepileptic drugs: Effects and unwanted effects. [In Japanese.] Jpn J Neuropsychopharmacol 1995;12:873883.
  • 9
    O'Brien, MD, Gilmour-White S. Epilepsy and pregnancy. BMJ 1993;307:492495.
  • 10
    Kaneko, S, Battino, D, Andermann, E, et al. International collaborative study on mechanisms of teratogenesis of antiepileptic drugs (A preliminary report) [in Japanese, abstract in English]. Ann Rep Jpn Epil Res Found 1993;5:191199.
  • 11
    Kaneko, S. Pregnancy and quality of life in women with epilepsy. Clinical Therapeutics 1998;20 (Suppl A):3047.
  • 12
    Lander, SM, Eadie, MJ. Plasma antiepileptic drug concentrations during pregnancy. Epilepsia 1991;32:257266.
  • 13
    Tomson, T, Lindbom, U, Ekqvist, B, Sundqvist, A. A prospective study of seizure control in relation to free and total plasma concentrations of carbamazepine and phenytoin. Epilepsia 1994;325:122130.
  • 14
    Kaneko, S, Battino, D, Andermann, E, et al. Congenital malformations due to antiepileptic drugs. Epilepsy Res 1999;33:145158.
  • 15
    Kaneko, S, Otani, K, Fukushima, Y, et al. Teratogenicity of antiepileptic drugs: analysis of possible risk factors. Epilepsia 1988;29:459467.
  • 16
    Kaneko, S, Otani, K, Kondo, T, et al. Malformation in infants of mothers with epilepsy receiving antiepileptic drugs. Neurology 1992;42(Suppl 5):68.
  • 17
    Hanson, JW, Smith, DW. The fetal hydantoin syndrome. J Pediatr 1975;87:285290.
  • 18
    Di Liberti, JM, Farndon, PA, Dennis, NR. The fetal valproate syndrome. Am J Med Genet 1984;19:473481.
  • 19
    Gaily, E, Granstrom, ML, Hiilesmaa, V, Bardy, A. Minor anomalies in offspring of epileptic mothers. J Pediatr 1988;112:520529.
  • 20
    Jager-Roman, E, Deichl, A, Jacob, S, et al. Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid. J Pediatr 1986;108:9971004.
  • 21
    Lindhout, D, Schmidt, D. In-utero-exposure to valproate and neural tube defects. Lancet 1986;1:13921393.
  • 22
    Rosa, FW. Spina bifida in infants of women treated with carba-mazepine during pregnancy. N Engl J Med 1991;342:674677.
  • 23
    Kaneko, S, Otani, K, Kondo, T, et al. Teartogenicity of antiepileptic drugs and drug specific malformations. Jpn J Psychiatr Neurol 1993;47:306308.
  • 24
    Kondo, T, Kaneko, S, Amano, Y, Egawa, I. Preliminary report on teratogenic effects of zonisamide in the offspring treated women with epilepsy. Epilepsia 1996;27: 12421244.
  • 25
    Dansky, L, Andermann, E, Andermann, F. Maternal epilepsy and congenital malformations: correlation with maternal plasma anti-convulsant levels during pregnancy. In: Janz, D, Dam, D, Richens, A, Bossi, L, Helge, H, Schmidt, D. eds. Epilepsy, Pregnancy, and the Child. New York : Raven Press, 1982:251258.
  • 26
    Kaneko, S. Major malformations in children of mothers with epilepsy. Eur J Neurol 1995:2(Suppl 4):5163.
  • 27
    Lindhout, D, Hoppener, RJEA, Meinardi, H. Teratogenicity of anti-epileptic drug combinations with special emphasis on epoxidation (of carbamazepine). Epilepsia 1984;25:7783.
  • 28
    Kitay, DZ. Folic acid and reproduction. Clin Obstet Gynecol 1979; 22:809817.
  • 29
    Meadow, SR. Anticonvulsant drugs and congenital abnormalities. Lancet 1968;2:1296.
  • 30
    Dansky, LV, Andermann, E, Rosenblatt, D, Sherwin, AL, Andermann, F. Anticonvulsants, folate levels, and pregnancy outcome: A prospective study. Ann Neurol 1987;21:176182.
  • 31
    Ogawa, Y, Kaneko, S, Otani, K, Fukushima, Y. Serum folic acid levels in epileptic mothers and their relationship to congenital malformations. Epilepsy Res 1991;8:7578.
  • 32
    Netzloff, ML, Streiff, RR, Frias, JL, Rennert, DM. Folate antagonism following teratogenic exposure to diphenylhydantoin. Teratology 1979;9:4550.
  • 33
    Wells, PG, Harbison, RD. Significance of the phenytoin reactive arene oxide intermediate, its oxepin tautomer, and clinical factors modifying their roles in phenytoin-induced teratology. In: Hassell, TH, Johnston, MC, Dudley, KH. eds. Phenytoin-induced teratology and gingival pathology. New York : Raven Press, 1980:83112.
  • 34
    Gaily, E, Granstrom, M-L. A transient retardation of early postnatal growth in drug exposed children of epileptic mothers. Epilepsy Res 1989;4:147155.
  • 35
    Ogawa, Y, Shinagawa, S, Kaneko, S, et al. Physical development in offspring born to treated epileptic mothers, with reference to various hormone levels. Advances in epileptology 1989;17:237241.
  • 36
    Battino, D, Kaneko, S, Aandermann, E, et al. Intrauterine growth in the offspring of epileptic women: a prospective multicenter study. Epilepsy Res 1999;36:5360.
  • 37
    Kaneko, S, Hirano, T, Muramatsu, E and Nomura, Y. Fetal and neonatal effects of antiepileptic drugs-the physical and psychomo-tor developments in the offspring of epileptic parents. In: Fujii, T and Adams, PM eds. Functional teratologenesis. Tokyo : Teikyo University Press. 1987; 205214.
  • 38
    Kaneko, S, Otani, K, Fukushima, Y, et al. Effects of antiepileptic drugs on hGH, TSH and thyroid hormone concentrations during pregnancy. Biol Res in Pregn 1982;3:148151.
  • 39
    Kaneko, S. Antiepileptic drug therapy of women with epilepsy of childbearing age: functional effects in offspring and developmental measures. In: Seki, T ed. Brain damage associated with prenatally environmental factors. Tokyo : Organizing committee of the 6th International symposium on developmental disabilities. 1994; 113122.
  • 40
    Gluckmann, PD and Liggins, GC. Regulation of fetal growth. In: Beard, RW and Nathanielsz, PW, eds. Productive medicine. No 6. New York : Marcel Dekker, 1984; 511557.
  • 41
    Liggins, GC, Kitterman, JA and Forster, CS. Fetal maturation related to parturition. Anim Reprod Sci 1979;2:193207.
  • 42
    Hirano, T, Okada, M, Mihara, K, et al. Antiepileptic drug therapy and folic acid supplementation. In: Fukushima, Y and Kaneko, S eds. Treatment of women with epilepsy of childbearing age. (in Japanese) Tokyo : Iwasaki Gakujyutu shuppan, 1993; 4958.