• 1
    Yerby MS, Friel PN, McCormick K. Antiepileptic drug disposition during pregnancy. Neurology 1992;42(suppl 5):1216.
  • 2
    Pennell PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 2003;61(suppl 2):S3542.
  • 3
    Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41: 70913.
  • 4
    Tran TA, Leppik IE, Blesi K, et al. Lamotrigine clearance during pregnancy. Neurology 2002;59: 251255.
  • 5
    Pennell PB, Newport DJ, Stowe ZN, et al. The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 2004;62: 292295.
  • 6
    De Haan GJ, Edelbroek P, Segers J, et al. Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study. Neurology 2004;63: 571573.
  • 7
    Artama M, Auvinen A, Raudaskoski T, et al. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 2005;64: 18741878.
  • 8
    Montouris G. Safety of the newer antiepileptic drug oxcarbazepine during pregnancy. Curr Med Res Opin 2005;21: 693701.
  • 9
    May TW, Korn-Merker E, Rambeck B. Clinical pharmacokinetics of oxcarbazepine. Clin Pharmacokinet 2003;42: 10231042.
  • 10
    Volosov A, Xiaodong S, Perucca E, et al. Enantioselective pharmacokinetics of 10-hydroxycarbazepine after oral administration of oxcarbazepine to healthy Chinese subjects. Clin Pharmacol Ther 1999;66: 547553.
  • 11
    Volosov A, Bialer M, Xiaodong S, et al. Simultaneous stereoselective high-performance liquid chromatographic determination of 10-hydroxycarbazepine and its metabolite carbamazepine-10,11-trans-dihydrodiol in human urine. J Chromatogr B 2000;738: 419425.
  • 12
    Flesch G, Francotte E, Hell F, et al. Determination of the R-(-) and S-(+) enantiomers of the monohydroxymetabolite of oxcarbazepine in human serum by enantioselective high-performance liquid chromatography. J Chromatogr 1992;581: 147151.
  • 13
    Benes J, Parada A, Figuereido A, et al. Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide derivatives. J Med Chem 1999;42: 25822587.
  • 14
    Bulau P, Paar WD, Von Unruh GE. Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother. Eur J Clin Pharmacol 1988;34: 311313.
  • 15
    Perucca E. Drug metabolism in pregnancy, infancy and childhood. Pharmacol Ther 1987;34: 129143.
  • 16
    Sabers A, Ohman I, Christensen J, Tomson T. Oral contraceptives reduce lamotrigine plasma levels. Neurology 2003;61: 570571.
  • 17
    Sabers A, Buchholt JM, Uldall P, et al. Lamotrigine plasma levels reduced by oral contraceptives. Epilepsy Res 2001;47: 151154.
  • 18
    Sidhu J, Bulsara S, Job S, et al. A bidirectional pharmacokinetic interaction study of lamotrigine and the combined oral contraceptive pill in healthy subjects. Epilepsia 2004;45(suppl 7):330.
  • 19
    EURAP Study Group. Seizure control and treatment in pregnancy: observations from EURAP, a prospective international registry of epilepsy, pregnancy and maternal use of antiepileptic drugs. Neurology 2005; Dec. 28, e-pub ahead of print.