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Language and Motor fMRI Activation in Polymicrogyric Cortex

  1. David Araujo1,
  2. Draulio B. De Araujo2,
  3. Octavio M. Pontes-Neto1,
  4. Sara Escorsi-Rosset1,
  5. Gustavo N. Simao3,
  6. Lauro Wichert-Ana1,
  7. Tonicarlo R. Velasco1,
  8. Americo C. Sakamoto1,
  9. Joao P. Leite1,
  10. Antonio C. Santos3

Article first published online: 6 MAR 2006

DOI: 10.1111/j.1528-1167.2006.00473.x

Issue

Epilepsia

Epilepsia

Volume 47, Issue 3, pages 589–592, March 2006

Additional Information

How to Cite

Araujo, D., De Araujo, D. B., Pontes-Neto, O. M., Escorsi-Rosset, S., Simao, G. N., Wichert-Ana, L., Velasco, T. R., Sakamoto, A. C., Leite, J. P. and Santos, A. C. (2006), Language and Motor fMRI Activation in Polymicrogyric Cortex. Epilepsia, 47: 589–592. doi: 10.1111/j.1528-1167.2006.00473.x

Author Information

  1. 1

    Neurology–FMRP

  2. 2

    Physics–FFCLRP

  3. 3

    Internal Medicine–FMRP, University of São Paulo, Ribeirao Preto, Brazil

*Address correspondence and reprint requests to Dr. A.C. Santos at Department of Internal Medicine, Radiology Center, Ribeirão Preto School of Medicine, University of São Paulo, 14051-140 Ribeirao Preto, SP, Brazil. E-mail: acsantos@fmrp.usp.br

Publication History

  1. Issue published online: 6 MAR 2006
  2. Article first published online: 6 MAR 2006
  3. Accepted October 16, 2005.

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Keywords:

  • Polymicrogyric cortex;
  • Functionality;
  • Functional MRI

Summary: Purpose: To analyze the patterns of brain activation in polymicrogyric cortex in epilepsy patients by blood oxygenation level–dependent (BOLD) functional MRI (fMRI), during language and motor activation tasks.

Methods: Five patients with extratemporal epilepsy associated with polymicrogyria were scanned in a 1.5-T Siemens scanner with BOLD fMRI sequences, by following language and motor paradigms. Functional images were processed by using Brain Voyager software.

Results: Activation of polymicrogyric cortex in the brain area that corresponds to the motor strip was present in all patients. Language studies revealed activation of polymicrogyric cortex over Broca's area in three cases.

Conclusions: Functionality was shown in polymicrogyric areas. Therefore if surgical resection is indicated, a careful functional planning is necessary because of functionality of the polymicrogyric cortex.

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