Deep Brain Stimulation of the Subthalamic Nucleus as Adjunct Treatment for Refractory Epilepsy
Article first published online: 19 JUL 2006
Volume 47, Issue 7, pages 1239–1241, July 2006
How to Cite
Handforth, A., DeSalles, A. A. F. and Krahl, S. E. (2006), Deep Brain Stimulation of the Subthalamic Nucleus as Adjunct Treatment for Refractory Epilepsy. Epilepsia, 47: 1239–1241. doi: 10.1111/j.1528-1167.2006.00563.x
- Issue published online: 19 JUL 2006
- Article first published online: 19 JUL 2006
- Accepted January 20, 2006.
- Deep brain stimulation;
Summary: Purpose: We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases.
Methods: This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected during a 3-4 month baseline, and for 26-32 months after DBS surgery, with AEDs held constant.
Results: Case 1, age 45, with bitemporal seizures, had about half the seizure frequency but still fell with injuries. Case 2, age 46, with left frontal encephalomalacia, had a frequency reduction of about one-third, but a more meaningful reduction of seizure severity and injuries.
Conclusions: Subthalamic DBS partly reduced partial-onset seizures, but the quality of life was more affected by seizure-related injuries.