Seizures and Antiepileptic Drugs: Does Exposure Alter Normal Brain Development?
Article first published online: 28 NOV 2006
Volume 47, Issue 12, pages 1999–2010, December 2006
How to Cite
Marsh, E. D., Brooks-Kayal, A. R. and Porter, B. E. (2006), Seizures and Antiepileptic Drugs: Does Exposure Alter Normal Brain Development?. Epilepsia, 47: 1999–2010. doi: 10.1111/j.1528-1167.2006.00894.x
- Issue published online: 28 NOV 2006
- Article first published online: 28 NOV 2006
- Accepted September 26, 2006.
- Antiepileptic drugs;
- Brain development;
- Cognitive studies
Summary: Seizures and antiepileptic drugs (AEDs) affect brain development and have long-term neurological consequences. The specific molecular and cellular changes, the precise timing of their influence during brain development, and the full extent of the long-term consequences of seizures and AEDs exposure have not been established. This review critically assesses both the basic and clinical science literature on the effects of seizures and AEDs on the developing brain and finds that evidence exists to support the hypothesis that both seizures and antiepileptic drugs influence a variety of biological process, at specific times during development, which alter long-term cognition and epilepsy susceptibility. More research, both clinical and experimental, is needed before changes in current clinical practice, based on the scientific data, can be recommended.