SEARCH

SEARCH BY CITATION

REFERENCES

  • Abbott NJ, Khan EU, Rollinson CM, Reichel A, Janigro D, Dombrowski SM, Dobbie MS, Begley DJ. (2002) Drug resistance in epilepsy: the role of the blood-brain barrier. Novartis Foundation Symposium 243:3847.
  • Awasthi S, Hallene KL, Fazio V, Singhal SS, Cucullo L, Awasthi YC, Dini G, Janigro D. (2005) RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neuroscience 6:61.
  • Booher J, Sensenbrenner M. (1972) Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures. Neurobiology 2:97105.
  • Brown RC, Egleton RD, Davis TP. (2004) Mannitol opening of the blood-brain barrier: regional variation in the permeability of sucrose, but not 86Rb+ or albumin. Brain Research 1014:221227.
  • Cornford EM, Nguyen EV, Landaw EM. (2000) Acute upregulation of blood-brain barrier glucose transporter activity in seizures. American Journal of Physiology Heart and Circulatory Physiology 279:H1346H1354.
  • Cucullo L, McAllister MS, Kight K, Krizanac-Bengez L, Marroni M, Mayberg MR, Stanness KA, Janigro D. (2002) A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier. Brain Research 951:243254.
  • Cucullo L, Aumayr B, Rapp E, Janigro D. (2005a) Drug delivery and in vitro models of the blood-brain barrier. Current Opinion in Drug Discovery Development 8:8999.
  • Cucullo L, Aumayr B, Rapp E, Janigro D. (2005b) Drug delivery and in vitro models of the blood-brain barrier. Current Opinion in Drug Discovery Development 8:8999.
  • Cucullo L, Oby E, Hallenbeck JM, Aumayr B, Rapp E, Janigro D. (2005c) Artificial blood-brain barrier. In DermietzelR, SprayDC, NedergaardM (Eds) Blood–brain interfaces: from ontogeny to artificial barriers. Wiley Press, Hoboken , NJ , pp. 375402.
  • Davson H, Segal MB. (1995) Blood-brain-CSF interactions. Physiology of the CSF and blood-brain barriers. CRC Press, Boca Raton , FL, pp. 257–302 .
  • Davson H, Segal MB. (1996) Blood-brain barrier. In DavsonH, SegalMB (Eds) Physiology of the CSF and blood-brain barriers. CRC Press, Boca Raton , FL , pp. 4991.
  • Desai SY, Marroni M, Cucullo L, Krizanac-Bengez L, Mayberg MR, Hossain MT, Grant GG, Janigro D. (2002) Mechanisms of endothelial survival under shear stress. Endothelium 9:89102.
  • Dombrowski SM, Desai SY, Marroni M, Cucullo L, Goodrich K, Bingaman W, Mayberg MR, Bengez L, Janigro D. (2001) Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42:15011506.
  • Gronlund KM, Gerhart DZ, Leino RL, McCall AL, Drewes LR. (1996) Chronic seizures increase glucose transporter abundance in rat brain. Journal of Neuropathology and Experimental Neurology 55:832840.
  • Janigro D, Leaman SM, Stanness KA. (1999) Dynamic modeling of the blood-brain barrier: a novel tool for studies of drug delivery to the brain. Pharmaceutical Science and Technology Today 2:712.
  • Janigro D, Stanness KA, Soderland C, Grant AG. (2000) Development of an in vitro blood-brain barrier. In CostaLG (Ed) Biochemical and molecular neurotoxicology. John Wiley & Sons, New York , 12.2.112.2.10.
  • Krizanac-Bengez L, Kapural M, Parkinson F, Cucullo L, Hossain M, Mayberg MR, Janigro D. (2003) Effects of transient loss of shear stress on blood-brain barrier endothelium: role of nitric oxide and IL-6. Brain Research 977:239246.
  • Loscher W. (2002a) Animal models of drug-resistant epilepsy. Novartis Foundation Symposium 243:149159.
  • Loscher W. (2002b) Current status and future directions in the pharmacotherapy of epilepsy. Trends in Pharmacological Science 23:113118.
  • Loscher W. (2005) How to explain multidrug resistance in epilepsy? Epilepsy Currents 5:107112.
  • Maines LW, Antonetti DA, Wolpert EB, Smith CD. (2005) Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology 49:610617.
  • Marchi N, Fazio V, Cucullo L, Kight K, Masary KTJ, Barnett G, Vogelbaum M, Kinter M, Mayberg MR, Janigro D. (2003) Serum transthyretin as a possible marker of blood-to-CSF barrier disruption. Journal of Neuroscience 23:19491955.
  • Marchi N, Guiso G, Rizzi M, Pirker S, Novak K, Czech T, Baumgartner C, Janigro D, Caccia S, Vezzani A. (2005) A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine. Epilepsia 46:16131619.
  • Marchi N, Hallene KL, Kight KM, Cucullo L, Moddel G, Bingaman W, Dini G, Vezzani A, Janigro D. (2004) Significance of MDR1 and multiple drug resistance in refractory human epileptic brain. BMC Medicine 2:37.
  • Marroni M, Kight KM, Hossain M, Cucullo L, Desai SY, Janigro D. (2003a) Dynamic in vitro model of the blood-brain barrier: gene profiling using cDNA microarray analysis. Methods in Molecular Medicine 89:419434.
  • Marroni M, Marchi N, Cucullo L, Abbott NJ, Signorelli K, Janigro D. (2003b) Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy. Current Drug Targets 4:297304.
  • Mashour GA, Boock RJ. (1999) Effects of shear stress on nitric oxide levels of human cerebral endothelial cells cultured in an artificial capillary system. Brain Research 842:233238.
  • Meyer J, Tauh J, Galla HG. (1991) The susceptibility of cerebral endothelial cells to astroglial induction of blood-brain barrier enzymes depends on their proliferative state. Journal of Neurochemistry 57:19711977.
  • Mistry P, Stewart AJ, Dangerfield W, Okiji S, Liddle C, Bootle D, Plumb JA, Templeton D, Charlton P. (2001) In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Research 61:749758.
  • Oby E, Caccia S, Vezzani A, Moeddel G, Hallene K, Guiso G, Said T, Bingaman W, Marchi N, Baumgartner C, Pirker S, Czech T, Lo Russo G, Janigro D. (2006) In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance. Brain Research 1086:201213.
  • Oby E, Janigro D. (2006) The blood-brain barrier and epilepsy. Epilepsia 47:17611774.
  • Ott MJ, Ballermann BJ. (1995) Shear stress-conditioned, endothelial cell-seeded vascular grafts: improved cell adherence in response to in vitro shear stress. Surgery 117:334339.
  • Patsalos PN, O'Connell MT, Doheny HC, Sander JW, Shorvon SD. (1996) Antiepileptic drug pharmacokinetics in patients with epilepsy using a new microdialysis probe: preliminary observations. Acta Neurochir Suppl 67:5962.
  • Potschka H, Baltes S, Loscher W. (2004) Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats. Epilepsy Research 58:8591.
  • Potschka H, Loscher W. (2001) Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain. Neuroreport 12:23872389.
  • Rapoport SI. (2000) Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cellular and Molecular Neurobiology 20:217230.
  • Rizzi M, Caccia S, Guiso G, Richichi C, Gorter JA, Aronica E, Aliprandi M, Bagnati R, Fanelli R, D'Incalci M, Samanin R, Vezzani A. (2002) Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. Journal of Neuroscience 22:58335839.
  • Santaguida S, Janigro D, Hossain M, Oby E, Rapp E, Cucullo L. (2006) Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: a permeability study. Brain Research 1109:113.
  • Schmidt D, Loscher W. (2005) Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 46:858877.
  • Stanness KA, Guatteo E, Janigro D. (1996) A dynamic model of the blood-brain barrier “in vitro.” Neurotoxicology 17:481496.
  • Stanness KA, Westrum LE, Fornaciari E, Mascagni P, Nelson JA, Stenglein SG, Myers T, Janigro D. (1997) Morphological and functional characterization of an in vitro blood-brain barrier model. Brain Research 771:329342.
  • Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C. (1995) MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36:16.
  • Van Vliet EA, Van Schaik R, Edelbroek PM, Redeker S, Aronica E, Wadman WJ, Marchi N, Vezzani A, Gorter JA. (2006) Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia 47:672680.
  • Volk HA, Loscher W. (2005) Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures. Brain 128:13581368.
  • Walker MC, Alavijeh MS, Shorvon SD, Patsalos PN. (1996) Microdialysis study of the neuropharmacokinetics of phenytoin in rat hippocampus and frontal cortex. Epilepsia 37:421427.
  • Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH. (2001) In vitro substrate identification studies for P-glycoprotein-mediated transport: species difference and predictability of in vivo results. Journal of Pharmacology and Experimental Therapy 296:723735.