Neonatal Seizures: Gaps Between the Laboratory and the Clinic
Article first published online: 1 JUN 2007
Volume 48, Issue Supplement s2, pages 83–106, April 2007
How to Cite
Lombroso, C. T. (2007), Neonatal Seizures: Gaps Between the Laboratory and the Clinic. Epilepsia, 48: 83–106. doi: 10.1111/j.1528-1167.2007.01070.x
- Issue published online: 1 JUN 2007
- Article first published online: 1 JUN 2007
- Neonatal seizures;
- Gaps between bench and crib
Summary: Seizures in neonates (NBs) remain the most frequent neurological problem in the nursery. Considerable debate about their consequences exists between data and deductions reached through animal experimentations and those obtained through clinical investigations. The main conflicting issues are whether seizures in NBs can plant the roots for epileptogenesis and cause long-term deficits. The purpose of this chapter is to evaluate both laboratory and clinical results.
Methods: Clinical data will be presented, including a 20-year-long cohort of NBs. This will be followed by the main seminal discoveries obtained in neonatal models. The phenomenon of transient or persistent dysmaturity following NB seizures will be discussed in relation to etiological factors.
Results: The findings and deductions from animal models support the notions that epileptogenesis and cognitive deficits result from NB seizures. These conclusions contrast with clinical investigations maintaining that NB seizures, per se, are symptomatic markers of preexisting or of ongoing morbidities. The reasons for contrasting views will be discussed. Suggestions will be advanced for more animal models whose seizures are consistent with the etiologies and the phenotypes of human NB seizures.