SEARCH

SEARCH BY CITATION

REFERENCES

  • Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. (1999) MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97:175187.
  • Ackerman MJ, Siu BL, Sturner WQ, Tester DJ, Valdivia CR, Makielski JC, Towbin JA. (2001) Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome. Journal of the American Medical Association 286:22642269.
  • Annegers J. (1997) United States perspective on definitions and classifications: International Workshop on Epilepsy and Sudden Death, Oct. 28, 1996. Epilepsia 38(suppl 11):S9S12.
  • Aydin A, Bahring S, Dahm S, Guenther UP, Uhlmann R, Busjahn A, Luft FC. (2005) Single nucleotide polymorphism map of five long-QT genes. Journal of Molecular Medicine 83:159165.
  • Baulac S, Huberfeld G, Gourfinkel-An I, Mitropoulou G, Beranger A, Prud'homme JF, Baulac M, Brice A, Bruzzone R, LeGuern E. (2001) First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nature Genetics 28:4648.
  • Bellocq C, Van Ginneken AC, Bezzina CR, Alders M, Escande D, Mannens MM, Baro I, Wilde AA. (2004) Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation 109:23942397.
  • Benson DW, Wang DW, Dyment M, Knilans TK, Fish FA, Strieper MJ, Rhodes TH, George AL Jr. (2003) Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). Journal of Clinical Investigations 112:10191028.
  • Berkovic SF, Heron SE, Giordano L, Marini C, Guerrini R, Kaplan RE, Gambardella A, Steinlein OK, Grinton BE, Dean JT, Bordo L, Hodgson BL, Yamamoto T, Mulley JC, Zara F, Scheffer IE. (2004) Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy. Annals of Neurology 55:550557.
  • Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK. (1998) A potassium channel mutation in neonatal human epilepsy. Science 279:403406.
  • Bird J, Dembny KAT, Sandeman D, Butler S. (1997) Sudden unexplained death in epilepsy: an intracranially monitored case: International Workshop on Epilepsy and Sudden Death, Oct 28, 1996. Epilepsia 38(suppl 11):S52S56.
  • Birnbach C, Wilensky A, Dodrill C. (1991) Predictors of early mortality and sudden death in epilepsy: a multidisciplinary approach. Journal of Epilepsy 4:1117.
  • Blum AS, Ives JR, Goldberger AL, Al-Aweel IC, Krishnamurthy KB, Drislane FW, Schomer DL. (2000) Oxygen desaturations triggered by partial seizures: implications for cardiopulmonary instability in epilepsy. Epilepsia 41:536541.
  • Bowerman DL, Levisky JA, Urich RW, Wittenberg PH. (1978) Premature deaths in persons with seizure disorders-subtherapeutic levels of anticonvulsant drugs in postmortem blood specimens. Journal of Forensic Science 23:522526.
  • Brugada R, Hong K, Cordeiro JM, Dumaine R. (2005) Short QT syndrome. Canadian Medical Association Journal 173:13491354.
  • Brugada R, Hong K, Dumaine R, Cordeiro J, Gaita F, Borggrefe M, Menendez TM, Brugada J, Pollevick GD, Wolpert C, Burashnikov E, Matsuo K, Wu YS, Guerchicoff A, Bianchi F, Giustetto C, Schimpf R, Brugada P, Antzelevitch C. (2004) Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation 109:3035.
  • Budde T, Meuth S, Pape HC. (2002) Calcium-dependent inactivation of neuronal calcium channels. Natural Review of Neuroscience 3:873883.
  • Budde T, Sieg F, Braunewell KH, Gundelfinger ED, Pape HC. (2000) Ca2+-induced Ca2+ release supports the relay mode of activity in thalamocortical cells. Neuron 26:483492.
  • Camfield CS, Camfield PR, Veugelers PJ. (2002) Death in children with epilepsy: a population-based study. Lancet 359:18911895.
  • Camfield P, Camfield C. (2005) Sudden unexpected death in people with epilepsy: a pediatric perspective. Seminar in Pediatric Neurology 12:1014.
  • Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, Leppert M. (1998) A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nature Genetics 18:5355.
  • Chen CC, Lamping KG, Nuno DW, Barresi R, Prouty SJ, Lavoie JL, Cribbs LL, England SK, Sigmund CD, Weiss RM, Williamson RA, Hill JA, Campbell KP. (2003) Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science 302:14161418.
  • Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q. (1998) Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 392:293296.
  • Chen S, Chung MK, Martin D, Rozich R, Tchou PJ, Wang Q. (2002) SNP S1103Y in the cardiac sodium channel gene SCN5A is associated with cardiac arrhythmias and sudden death in a white family. Journal of Medical Genetics 39:913915.
  • Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou CP, Chen Z, Barhanin J, Huang W. (2003) KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299:251254.
  • Christiansen A, Tonder N, Larsen LA, Andersen PS, Simonsen H, Oyen N, Kanters JK, Jacobsen JR, Fosdal I, Wettrell G, Kjeldsen K. (2005) Mutations in the HERG K+-ion channel: a novel link between long QT syndrome and sudden infant death syndrome. American Journal of Cardiology 95:433434.
  • Claes L, Del Favero J, Ceulemans B, Lagae L, Van Broeckhoven C, De Jonghe P. (2001) De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy. American Journal of Human Genetics 68:13271332.
  • Cossette P, Liu L, Brisebois K, Dong H, Lortie A, Vanasse M, Saint-Hilaire JM, Carmant L, Verner A, Lu WY, Wang YT, Rouleau GA. (2002) Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Nature Genetics 31:184189.
  • Cribbs LL, Lee JH, Yang J, Satin J, Zhang Y, Daud A, Barclay J, Williamson MP, Fox M, Rees M, Perez-Reyes E. (1998) Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circulation Research 83:103109.
  • Dasheiff RM. (1991) Sudden unexpected death in epilepsy: a series from an epilepsy surgery program and speculation on the relationship to sudden cardiac death. Journal of Clinical Neurophysiology 8:216222.
  • Davis GG, McGwin G Jr. (2004) Comparison of heart mass in seizure patients dying of sudden unexplained death in epilepsy to sudden death due to some other cause. American Journal of Forensic Medical Pathology 25:2328.
  • Decher N, Bundis F, Vajna R, Steinmeyer K. (2003) KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. Pflugers Archives 446:633640.
  • Donahue LM, Coates PW, Lee VH, Ippensen DC, Arze SE, Poduslo SE. (2000) The cardiac sodium channel mRNA is expressed in the developing and adult rat and human brain. Brain Research 887:335343.
  • Donner EJ, Smith CR, Snead OC 3rd. (2001) Sudden unexplained death in children with epilepsy. Neurology 57:430434.
  • Dravet C, Bureau M, Guerrini R, Giraud N, Roger J. (1992) Severe myoclonic epilepsy in infants. In RogerJ, BureauM, DravetC, DreifussFE, PerretA, WolfP (Eds.) Epileptic syndromes in infancy, childhood and adolescence. John Libbey, London , pp. 7588.
  • Dwyer T, Ponsonby AL, Newman NM, Gibbons LE. (1991) Prospective cohort study of prone sleeping position and sudden infant death syndrome. Lancet 337:12441247.
  • Escayg A, MacDonald BT, Meisler MH, Baulac S, Huberfeld G, An-Gourfinkel I, Brice A, LeGuern E, Moulard B, Chaigne D, Buresi C, Malafosse A. (2000) Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2. Nature Genetics 24:343345.
  • Ficker DM, So EL, Shen WK, Annegers JF, O'Brien PC, Cascino GD, Belau PG. (1998) Population-based study of the incidence of sudden unexplained death in epilepsy. Neurology 51:12701274.
  • Forsgren L, Hauser WA, Olafsson E, Sander JW, Sillanpaa M, Tomson T. (2005) Mortality of epilepsy in developed countries: a review. Epilepsia 46(suppl 11):1827.
  • Fusco MD, Becchetti A, Patrignani A, Annesi G, Gambardella A, Quattrone A, Ballabio A, Wanke E, Casari G. (2000) The nicotinic receptor beta2 subunit is mutant in nocturnal frontal lobe epilepsy. Nature Genetics 26:275276.
  • Gargus JJ. (2006) Ion channel functional candidate genes in multigenic neuropsychiatric disease. Biological Psychiatry 60:177185.
  • Geelen JL, Doevendans PA, Jongbloed RJ, Wellens HJ, Geraedts JP. (1998) Molecular genetics of inherited long QT syndromes. European Heart Journal 19:14271433.
  • George JR, Davis GG. (1998) Comparison of anti-epileptic drug levels in different cases of sudden death. Journal of Forensic Science 43:598603.
  • Gong Q, Keeney DR, Robinson JC, Zhou Z. (2004) Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome. Journal of Molecular and Cellular Cardiology 37:12251233.
  • Harkin LA, Bowser DN, Dibbens LM, Singh R, Phillips F, Wallace RH, Richards MC, Williams DA, Mulley JC, Berkovic SF, Scheffer IE, Petrou S. (2002) Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. American Journal of Human Genetics 70:530536.
  • Haug K, Warnstedt M, Alekov AK, Sander T, Ramirez A, Poser B, Maljevic S, Hebeisen S, Kubisch C, Rebstock J, Horvath S, Hallmann K, Dullinger JS, Rau B, Haverkamp F, Beyenburg S, Schulz H, Janz D, Giese B, Muller-Newen G, Propping P, Elger CE, Fahlke C, Lerche H, Heils A. (2003) Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nature Genetics 33:527532.
  • Hell JW, Westenbroek RE, Warner C, Ahlijanian MK, Prystay W, Gilbert MM, Snutch TP, Catterall WA. (1993) Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits. Journal of Cellular Biology 123:949962.
  • Hennessy MJ, Tighe MG, Binnie CD, Nashef L. (2001) Sudden withdrawal of carbamazepine increases cardiac sympathetic activity in sleep. Neurology 57:16501654.
  • Heron SE, Crossland KM, Andermann E, Phillips HA, Hall AJ, Bleasel A, Shevell M, Mercho S, Seni MH, Guiot MC, Mulley JC, Berkovic SF, Scheffer IE. (2002) Sodium-channel defects in benign familial neonatal-infantile seizures. Lancet 360:851852.
  • Hirose S, Iwata H, Akiyoshi H, Kobayashi K, Ito M, Wada K, Kaneko S, Mitsudome A. (1999) A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy. Neurology 53:174953.
  • Jay GW, Leestma JE. (1981) Sudden death in epilepsy. a comprehensive review of the literature and proposed mechanisms. Acta Neurologica Scandavicas suppl 82:166.
  • Jervell A, Lange-Nielsen F. (1957) Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. American Heart Journal 54:5968.
  • Johnston SC, Siedenberg R, Min JK, Jerome EH, Laxer KD. (1997) Central apnea and acute cardiac ischemia in a sheep model of epileptic sudden death. Annals of Neurology 42:588594.
  • Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker-Cummings C, Martinelli Boneschi F, Choi C, Morozov P, Das K, Teplitskaya E, Yu A, Cayanis E, Penchaszadeh G, Kottmann AH, Pedley TA, Hauser WA, Ottman R, Gilliam TC. (2002) Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nature Genetics 30:335341.
  • Kano M, Garaschuk O, Verkhratsky A, Konnerth A. (1995) Ryanodine receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurones. Journal of Physiology 487:116.
  • Kass RS, Moss AJ. (2003) Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias. Journal of Clinical Investigations 112:810815.
  • Kenneback G, Ericson M, Tomson T, Bergfeldt L. (1997) Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs: implications for sudden death. Seizure 6:369375.
  • Kloster R, Engelskjon T. (1999) Sudden unexpected death in epilepsy (SUDEP): a clinical perspective and a search for risk factors. Journal of Neurology, Neurosurgery and Psychiatry 67:439444.
  • Langan Y, Nashef L, Sander JW. (2000) Sudden unexpected death in epilepsy: a series of witnessed deaths. Journal of Neurology, Neurosurgery and Psychiatry 68:211213.
  • Langan Y, Nashef L, Sander JW. (2005) Case-control study of SUDEP. Neurology 64:11311133.
  • Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. (2004) Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation 109:32083214.
  • Lehnart SE, Wehrens XH, Kushnir A, Marks AR. (2004) Cardiac ryanodine receptor function and regulation in heart disease. Annals of the New York Academy of Science 1015:144159.
  • Lhatoo SD, Sander JW. (2005) Cause-specific mortality in epilepsy. Epilepsia 46(suppl 11):3639.
  • Liljelund P, Netzeband JG, Gruol DL. (2000) L-Type calcium channels mediate calcium oscillations in early postnatal Purkinje neurons. Journal of Neuroscience 20:73947403.
  • Lipscombe D, Helton TD, Xu W. (2004) L-type calcium channels: the low down. Journal of Neurophysiology 92:26332641.
  • Lossin C, Wang DW, Rhodes TH, Vanoye CG, George AL Jr. (2002) Molecular basis of an inherited epilepsy. Neuron 34:877884.
  • Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F. (2003) Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J 22:216224.
  • Ludwig A, Flockerzi V, Hofmann F. (1997) Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain. Journal of Neuroscience 17:13391349.
  • Lund A, Gormsen H. (1985) The role of antiepileptics in sudden death in epilepsy. Acta Neurologica Scandinavica 72:444446.
  • Maier SK, Westenbroek RE, McCormick KA, Curtis R, Scheuer T, Catterall WA. (2004) Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation 109:14211427.
  • Makita N, Horie M, Nakamura T, Ai T, Sasaki K, Yokoi H, Sakurai M, Sakuma I, Otani H, Sawa H, Kitabatake A. (2002) Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation. Circulation 106:12691274.
  • Mangoni ME, Couette B, Bourinet E, Platzer J, Reimer D, Striessnig J, Nargeot J. (2003) Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity. Proceedings of the National Academy of Science United States of America 100:55435548.
  • Martin C, Chapman KE, Seckl JR, Ashley RH. (1998) Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. Neuroscience 85:205216.
  • McCrossan ZA, Abbott GW. (2004) The MinK-related peptides. Neuropharmacology 47:787821.
  • Mohler PJ, Bennett V. (2005) Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting. Current Opinion in Cardiology 20:189193.
  • Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V. (2004) A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proceedings of the National Academy of Science United States of America 101:91379142.
  • Moosmang S, Biel M, Hofmann F, Ludwig A. (1999) Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biological Chemistry 380:975980.
  • Moosmang S, Stieber J, Zong X, Biel M, Hofmann F, Ludwig A. (2001) Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. European Journal of Biochemistry 268:16461652.
  • MRC. (1991) Randomised study of antiepileptic drug withdrawal in patients in remission: Medical Research Council Antiepileptic Drug Withdrawal Study Group. Lancet 337:11751180.
  • Nashef L. (1997) Sudden unexpected death in epilepsy: terminology and definitions: International Workshop on Epilepsy and Sudden Death, Oct 28, 1996. Epilepsia 38(suppl 11):S6S8.
  • Nashef L. (2004) Sudden death in epilepsy. In ShorvonS, PerruccaE, FishD, DodsonE (Eds). The treatment of epilepsy. 2nd ed. Blackwell, New York , pp. 4349.
  • Nashef L, Garner S, Sander JW, Fish DR, Shorvon SD. (1998) Circumstances of death in sudden death in epilepsy: interviews of bereaved relatives. Journal of Neurology, Neurosurgery and Psychiatry 64:349352.
  • Nashef L, Walker F, Allen P, Sander JW, Shorvon SD, Fish DR. (1996) Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy. Journal of Neurology, Neurosurgery and Psychiatry 60:297300.
  • Natelson BH, Suarez RV, Terrence CF, Turizo R. (1998) Patients with epilepsy who die suddenly have cardiac disease. Archives of Neurology 55:857860.
  • Nei M, Ho RT, Sperling MR. (2000) ECG abnormalities during partial seizures in refractory epilepsy. Epilepsia 41:542548.
  • Nilsson L, Bergman U, Diwan V, Farahmand BY, Persson PG, Tomson T. (2001) Antiepileptic drug therapy and its management in sudden unexpected death in epilepsy: a case-control study. Epilepsia 42:667673.
  • Nilsson L, Farahmand BY, Persson PG, Thiblin I, Tomson T. (1999) Risk factors for sudden unexpected death in epilepsy: a case-control study. Lancet 353:888893.
  • O'Donoghue M, Sander JWAS. (1997) The mortality associated with epilepsy, with particular reference to sudden unexpected death: a review: International Workshop on Epilepsy and Sudden Death, Oct 28, 1996. Epilepsia 38(suppl 11):S15S19.
  • O'Regan ME, Brown JK. (2005) Abnormalities in cardiac and respiratory function observed during seizures in childhood. Devopmental Medicine and Child Neurology 47:49.
  • Opeskin K, Burke MP, Cordner SM, Berkovic SF. (1999) Comparison of antiepileptic drug levels in sudden unexpected deaths in epilepsy with deaths from other causes. Epilepsia 40:17951758.
  • Opeskin K, Thomas A, Berkovic SF. (2000) Does cardiac conduction pathology contribute to sudden unexpected death in epilepsy? Epilepsy Research 40:1724.
  • Opherk C, Coromilas J, Hirsch LJ. (2002) Heart rate and EKG changes in 102 seizures: analysis of influencing factors. Epilepsy Research 52:117127.
  • Otto E, Kunimoto M, McLaughlin T, Bennett V. (1991) Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes. Journal of Cellular Biology 114:241253.
  • P-Codrea Tigaran S, Dalager-Pedersen S, Baandrup U, Dam M, Vesterby-Charles A. (2005) Sudden unexpected death in epilepsy: is death by seizures a cardiac disease? American Journal of Forensic Medicine and Pathology 26:99105.
  • Pape HC, Munsch T, Budde T. (2004) Novel vistas of calcium-mediated signalling in the thalamus. Pflugers Archives 448:131138.
  • Persson H, Ericson M, Tomson T. (2003) Carbamazepine affects autonomic cardiac control in patients with newly diagnosed epilepsy. Epilepsy Research 57:6975.
  • Persson H, Kumlien E, Ericson M, Tomson T. (2005) Preoperative heart rate variability in relation to surgery outcome in refractory epilepsy. Neurology 65:10211025.
  • Plant LD, Bowers PN, Liu Q, Morgan T, Zhang T, State MW, Chen W, Kittles RA, Goldstein SA. (2006) A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. Journal of Clinical Investigations 116:430435.
  • Plaster NM, Tawil R, Tristani-Firouzi M, Canun S, Bendahhou S, Tsunoda A, Donaldson MR, Iannaccone ST, Brunt E, Barohn R, Clark J, Deymeer F, George AL Jr, Fish FA, Hahn A, Nitu A, Ozdemir C, Serdaroglu P, Subramony SH, Wolfe G, Fu YH, Ptacek LJ. (2001) Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell 105:511519.
  • Priori SG, Napolitano C. (2004) Genetics of cardiac arrhythmias and sudden cardiac death. Annals of the New York Academy of Science 1015:96110.
  • Priori SG, Napolitano C, Tiso N, Memmi M, Vignati G, Bloise R, Sorrentino V, Danieli GA. (2001) Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation 103:196200.
  • Priori SG, Pandit SV, Rivolta I, Berenfeld O, Ronchetti E, Dhamoon A, Napolitano C, Anumonwo J, Di Barletta MR, Gudapakkam S, Bosi G, Stramba-Badiale M, Jalife J. (2005) A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circulation Research 96:800807.
  • Puranik R, Chow CK, Duflou JA, Kilborn MJ, McGuire MA. (2005) Sudden death in the young. Heart Rhythm 2:12771282.
  • Qu J, Kryukova Y, Potapova IA, Doronin SV, Larsen M, Krishnamurthy G, Cohen IS, Robinson RB. (2004) MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes. Journal of Biological Chemistry 279:4349743502.
  • Raab-Graham KF, Radeke CM, Vandenberg CA. (1994) Molecular cloning and expression of a human heart inward rectifier potassium channel. Neuroreport 5:25012505.
  • Ravn LS, Hofman-Bang J, Dixen U, Larsen SO, Jensen G, Haunso S, Svendsen JH, Christiansen M. (2005) Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation. American Journal of Cardiology 96:405407.
  • Rhodes TH, Vanoye CG, Ohmori I, Ogiwara I, Yamakawa K, George AL Jr. (2005) Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures. Journal of Physiology 569:433445.
  • Robbins J. (2001) KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacological Therapeutics 90:119.
  • Rocamora R, Kurthen M, Lickfett L, Von Oertzen J, Elger CE. (2003) Cardiac asystole in epilepsy: clinical and neurophysiologic features. Epilepsia 44:179185.
  • Rogawski MA. (2000) KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy. Trends in Neuroscience 23:393398.
  • Rugg-Gunn FJ, Simister RJ, Squirrell M, Holdright DR, Duncan JS. (2004) Cardiac arrhythmias in focal epilepsy: a prospective long-term study. Lancet 364:22122219.
  • Ryvlin P, Montavont A, Kahane P. (2005) The impact of epilepsy surgery on mortality. Epileptic Disorders 7(suppl 1):3946.
  • Schott JJ, Alshinawi C, Kyndt F, Probst V, Hoorntje TM, Hulsbeek M, Wilde AA, Escande D, Mannens MM, Le Marec H. (1999) Cardiac conduction defects associate with mutations in SCN5A. Nature Genetics 23:201.
  • Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D. (2003) Pacemaker channel dysfunction in a patient with sinus node disease. Journal of Clinical Investigations 111:15371545.
  • Schwartz PJ. (2004) Stillbirths, sudden infant deaths, and long-QT syndrome: puzzle or mosaic, the pieces of the jigsaw are being fitted together. Circulation 109:29302932.
  • Schwartz PJ, Priori SG, Bloise R, Napolitano C, Ronchetti E, Piccinini A, Goj C, Breithardt G, Schulze-Bahr E, Wedekind H, Nastoli J. (2001) Molecular diagnosis in a child with sudden infant death syndrome. Lancet 358:134213543.
  • Schwartz PJ, Priori SG, Dumaine R, Napolitano C, Antzelevitch C, Stramba-Badiale M, Richard TA, Berti MR, Bloise R. (2000) A molecular link between the sudden infant death syndrome and the long-QT syndrome. New England Journal of Medicine 343:262267.
  • Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating MT, Towbin JA, Beggs AH, Brink P, Wilde AA, Toivonen L, Zareba W, Robinson JL, Timothy KW, Corfield V, Wattanasirichaigoon D, Corbett C, Haverkamp W, Schulze-Bahr E, Lehmann MH, Schwartz K, Coumel P, Bloise R. (2001) Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 103:8995.
  • Schwartz PJ, Stramba-Badiale M, Segantini A, Austoni P, Bosi G, Giorgetti R, Grancini F, Marni ED, Perticone F, Rosti D, Salice P. (1998) Prolongation of the QT interval and the sudden infant death syndrome. New England Journal of Medicine 338:17091714.
  • Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P, Kaupp UB. (1999) Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proceedings of the National Academy of Science United States of America 96:93919396.
  • Sillanpaa M, Jalava M, Kaleva O, Shinnar S. (1998) Long-term prognosis of seizures with onset in childhood. New England Journal of Medicine 338:17151722.
  • Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, Ronen GM, Bjerre I, Quattlebaum T, Murphy JV, McHarg ML, Gagnon D, Rosales TO, Peiffer A, Anderson VE, Leppert M. (1998) A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nature Genetics 18:2529.
  • So EL, Sam MC, Lagerlund TL. (2000) Postictal central apnea as a cause of SUDEP: evidence from near-SUDEP incident. Epilepsia 41:14941497.
  • Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC, Keating MT. (2005) Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proceedings of the National Academy of Science United States of America 102:80898096.
  • Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT. (2004) Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119:1931.
  • Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. (2002) Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 297:13331336.
  • Steinlein OK, Mulley JC, Propping P, Wallace RH, Phillips HA, Sutherland GR, Scheffer IE, Berkovic SF. (1995) A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nature Genetics 11:201203.
  • Steinlein OK, Stoodt J, Biervert C, Janz D, Sander T. (1999) The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy. Neuroreport 10:11631166.
  • Stieber J, Herrmann S, Feil S, Loster J, Feil R, Biel M, Hofmann F, Ludwig A. (2003) The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proceedings of the National Academy of Science United States of America 100:1523515240.
  • Stollberger C, Finsterer J. (2004) Cardiorespiratory findings in sudden unexplained/unexpected death in epilepsy (SUDEP). Epilepsy Research 59:5160.
  • Striano P, Bordo L, Lispi ML, Specchio N, Minetti C, Vigevano F, Zara F. (2006) A novel SCN2A mutation in family with benign familial infantile seizures. Epilepsia 47:218220.
  • Sugawara T, Tsurubuchi Y, Agarwala KL, Ito M, Fukuma G, Mazaki-Miyazaki E, Nagafuji H, Noda M, Imoto K, Wada K, Mitsudome A, Kaneko S, Montal M, Nagata K, Hirose S, Yamakawa K. (2001) A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proceedings of the National Academy of Science United States of America 98:63846389.
  • Suzuki T, Delgado-Escueta AV, Aguan K, Alonso ME, Shi J, Hara Y, Nishida M, Numata T, Medina MT, Takeuchi T, Morita R, Bai D, Ganesh S, Sugimoto Y, Inazawa J, Bailey JN, Ochoa A, Jara-Prado A, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, Yamakawa K. (2004) Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nature Genetics 36:8429.
  • Swallow RA, Hillier CE, Smith PE. (2002) Sudden unexplained death in epilepsy (SUDEP) following previous seizure-related pulmonary oedema: case report and review of possible preventative treatment. Seizure 11:446448.
  • Tavernor SJ, Brown SW, Tavernor RM, Gifford C. (1996) Electrocardiograph QT lengthening associated with epileptiform EEG discharges: a role in sudden unexplained death in epilepsy? Seizure 5:7983.
  • Tester DJ, Spoon DB, Valdivia HH, Makielski JC, Ackerman MJ. (2004) Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner's cases. Mayo Clinic Proceedings 79:13801384.
  • Timmings PL. (1998) Sudden unexpected death in epilepsy: is carbamazepine implicated? Seizure 7:289291.
  • Tinel N, Diochot S, Lauritzen I, Barhanin J, Lazdunski M, Borsotto M. (2000) M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. FEBS Letters 480:137141.
  • Tiso N, Stephan DA, Nava A, Bagattin A, Devaney JM, Stanchi F, Larderet G, Brahmbhatt B, Brown K, Bauce B, Muriago M, Basso C, Thiene G, Danieli GA, Rampazzo A. (2001) Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Human Molecular Genetics 10:189194.
  • Tomson T, Ericson M, Ihrman C, Lindblad LE. (1998) Heart rate variability in patients with epilepsy. Epilepsy Research 30:7783.
  • Tomson T, Skold AC, Holmgen P, Nilsson L, Danielsson B. (1998) Postmortem changes in blood concentrations of phenytoin and carbamazepine: an experimental study. Therpeutic Drug Monitoring 20:309312.
  • Tomson T, Walczak T, Sillanpaa M, Sander JW. (2005) Sudden unexpected death in epilepsy: a review of incidence and risk factors. Epilepsia 46(suppl 11):5461.
  • Tristani-Firouzi M, Jensen JL, Donaldson MR, Sansone V, Meola G, Hahn A, Bendahhou S, Kwiecinski H, Fidzianska A, Plaster N, Fu YH, Ptacek LJ, Tawil R. (2002) Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome). Journal of Clinical Investigations 110:381388.
  • Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A. (2004) Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. Journal of Biological Chemistry 279:2719427198.
  • Ulrich J, Maxeiner H. (2003) Tongue bite injuries: a diagnostic criterion for death in epileptic seizure? Archives Kriminologe 212:1929.
  • Vincent GM. (1998) The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. Annual Review of Medicine 49:263274.
  • Viswanathan PC, Benson DW, Balser JR. (2003) A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation. Journal of Clinical Investigations 111:341416.
  • Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E. (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. Journal of Neuroscience 25:48444855.
  • Walczak TS, Leppik IE, D'Amelio M, Rarick J, So E, Ahman P, Ruggles K, Cascino GD, Annegers JF, Hauser WA. (2001) Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study. Neurology 56:519525.
  • Wallace RH, Marini C, Petrou S, Harkin LA, Bowser DN, Panchal RG, Williams DA, Sutherland GR, Mulley JC, Scheffer IE, Berkovic SF. (2001) Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nature Genetics 28:4952.
  • Wallace RH, Wang DW, Singh R, Scheffer IE, George AL Jr, Phillips HA, Saar K, Reis A, Johnson EW, Sutherland GR, Berkovic SF, Mulley JC. (1998) Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nature Genetics 19:366370.
  • Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, Moss AJ, Towbin JA, Keating MT. (1995) SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80:805811.
  • Weber P, Bubl R, Blauenstein U, Tillmann BU, Lutschg J. (2005) Sudden unexplained death in children with epilepsy: a cohort study with an eighteen-year follow-up. Acta Paediatrica 94:564567.
  • Williams J, Lawthom C, Dunstan FD, Dawson TP, Kerr MP, Wilson JF, Smith PE. (2006) Variability of antiepileptic medication taking behaviour in sudden unexplained death in epilepsy: hair analysis at autopsy. Journal of Neurology, Neurosurgery and Psychiatry 77:481484.
  • Wu L, Nishiyama K, Hollyfield JG, Wang Q. (2002) Localization of Nav1.5 sodium channel protein in the mouse brain. Neuroreport 13:25472551.
  • Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS. (1997) Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Circulation Research 80:261268.
  • Yang P, Kanki H, Drolet B, Yang T, Wei J, Viswanathan PC, Hohnloser SH, Shimizu W, Schwartz PJ, Stanton M, Murray KT, Norris K, George AL Jr, Roden DM. (2002) Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation 105:19431948.
  • Yu H, Wu J, Potapova I, Wymore RT, Holmes B, Zuckerman J, Pan Z, Wang H, Shi W, Robinson RB, El Maghrabi MR, Benjamin W, Dixon J, McKinnon D, Cohen IS, Wymore R. (2001) MinK-related peptide 1: a beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circulation Research 88:E84E87.