SEARCH

SEARCH BY CITATION

REFERENCES

  • Abdelhadi M, Ericzon BG, Hultenby K, Sjoden G, Reinholt FP, Nordenstrom J. (2002) Structural skeletal impairment induced by immunosuppressive therapy in rats: cyclosporine A vs tacrolimus. Transpl Int 15:180187.
  • Abou-Khalil B. (2005) Benefit-risk assessment of levetiracetam in the treatment of partial seizures. Drug Saf 28:871890.
  • Andress DL, Ozuna J, Tirschwell D, Grande L, Johnson M, Jacobson AF, Spain W. (2002) Antiepileptic drug-induced bone loss in young male patients who have seizures. Arch Neurol 59:781786.
  • Blum AS. (2002) Recurrent generalized and partial seizures. In  JohnsonRT, GriffinJW, McArthurJC (Eds) Current therapy in neurologic disease, Mosby, Inc., Philadelphia , p. 46.
  • Bonaventura Cd, Mari F, Fattouch J, Egeo G, Vaudano AE, Manfredi M, Prencipe M, Giallonardo AT. (2006) Use of levetiracetam in treating epilepsy associated with other medical conditions. Acta Neurol Scand 113:8286.
  • Briggs DE, French JA. (2004) Levetiracetam safety profiles and tolerability in epilepsy patients. Expert Opinion on Drug Safety 3:415424.
  • Brzoska MM, Moniuszko-Jakoniuk J. (2004) Low-level lifetime exposure to cadmium decreases skeletal mineralization and enhances bone loss in aged rats. Bone 35:11801191.
  • Chifari R, Testolin C, Canevini MP, Piazzini A, Gambardella A, Viri M, Romeo A, Russo A, Canger R. (2003) Increased risk of decreased bone density in adults receiving long-term antiepileptic therapy. Epilepsia 44:276 (abstract).
  • Cho HH, Park HT, Kim YJ, Bae YC, Suh KT, Jung JS. (2005) Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. J Cell Biochem 96:533542.
  • Crawford P. (2005) Best practice guidelines for the management of women with epilepsy. Epilepsia 46(suppl 9):117124.
  • Dziak R, Vernillo A, Rifkin B. (1988) The effects of phenytoin on calcium uptake in osteoblastic cells. J Bone Miner Res 3:415420.
  • Eleftheriades MI, Lambrinoudaki IV, Christodoulakos GE, Gregoriou OV, Economou EV, Kouskouni EE, Antoniou AG, Perrea DN, Dontas IA, Raptou PD, Lyritis GP, Creatsas GC. (2005) Effect of oral contraceptive treatment on bone mass acquisition in skeletally immature young female rats. Contraception 71:362371.
  • Ensrud KE, Walczak TS, Blackwell T, Ensrud ER, Bowman PJ, Stone KL. (2004) Antiepileptic drug use increases rates of bone loss in older women: a prospective study. Neurology 62:20512057.
  • Farhat G, Yamout B, Mikati MA, Demirjian S, Sawaya R, El-Hajj FG. (2002) Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology 58:13481353.
  • Feldkamp J, Becker A, Witte OW, Scharff D, Scherbaum WA. (2000) Long-term anticonvulsant therapy leads to low bone mineral density–evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells. Experimental and Clinical Endocrinology & Diabetes 108:3743.
  • Gough H, Goggin T, Bissessar A, Baker M, Crowley M, Callaghan N. (1986) A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy. The Quarterly Journal of Medicine 59:569577.
  • Gracious B, Bossert RP, Puzas JE. (2004) Valproic acid inhibits osteoblast and osteoclast activity in therapeutic dose ranges. J Bone Miner Res (Suppl):M405 (abstract).
  • Gu J, Lynch BA, Anderson D, Klitgaard H, Lu S, Elashoff M, Ebert U, Potschka H, Loscher W. (2004) The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats. Eur J Neurosci 19:334345.
  • Guo CY, Ronen GM, Atkinson SA. (2001) Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. Epilepsia 42:11411147.
  • Ikedo D, Ohishi K, Yamauchi N, Kataoka M, Kido J, Nagata T. (1999) Stimulatory effects of phenytoin on osteoblastic differentiation of fetal rat calvaria cells in culture. Bone 25:653660.
  • Isojarvi JI, Tauboll E, Pakarinen AJ, Van PJ, Rattya J, Harbo HF, Dale PO, Fauser BC, Gjerstad L, Koivunen R, Knip M, Tapanainen JS. (2001) Altered ovarian function and cardiovascular risk factors in valproate-treated women. Am J Med 111:290296.
  • Jayo MJ, Register TC, Hughes CL, Blas-Machado U, Sulistiawati E, Borgerink H, Johnson CS. (2000) Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats. J Soc Gynecol Investig 7:257265.
  • Johannessen SI, Battino D, Berry DJ, Bialer M, Kramer G, Tomson T, Patsalos PN. (2003) Therapeutic drug monitoring of the newer antiepileptic drugs. Ther Drug Monit 25:347363.
  • Kaastad TS, Reikeras O, Halvorsen V, Falch JA, Obrant KJ, Nordsletten L. (2001) Vitamin D deficiency and ovariectomy reduced the strength of the femoral neck in rats. Calcif Tissue Int 69:102108.
  • Kinjo M, Setoguchi S, Schneeweiss S, Solomon DH. (2005) Bone mineral density in subjects using central nervous system-active medications. Am J Med 118:1414.
  • Kubota F, Kifune A, Shibata N, Akata T, Takeuchi K, Takahashi S, Ohsawa M, Takama F. (1999) Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: a quantitative digital radiography study. Epilepsy Res 33:9397.
  • Kulak CA, Borba VZ, Bilezikian JP, Silvado CE, Paola L, Boguszewski CL. (2004) Bone mineral density and serum levels of 25 OH vitamin D in chronic users of antiepileptic drugs. Arqu Neuropsiquiatr 62:940948.
  • Lau KHW, Nakade O, Barr B, Taylor AK, Houchin K, Baylink DJ. (1995) Phenytoin increases markers of osteogenesis for the human species in-vitro and in-vivo. J Clin Endocrinol Metab 80:23472353.
  • Lofgren E, Mikkonen K, Tolonen U, Pakarinen A, Koivunen R, Myllyla VV, Tapanainen JS, Isojarvi JIT. (2007) Reproductive endocrine function in women with epilepsy: The role of epilepsy type and medication. Epilepsy & Behavior 10:7783.
  • Loscher W. (1999) Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Progress in Neurobiology 58:3159.
  • Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B. (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proceedings of the National Academy of Sciences of the United States of America 101:98619866.
  • Nordahl J, Andersson G, Reinholt FP. (1998) Chondroclasts and osteoclasts in bones of young rats: comparison of ultrastructural and functional features. Calcif Tissue Int 63:401408.
  • Nordahl J, Hollberg K, Mengarelli-Widholm S, Andersson G, Reinholt FP. (2000) Morphological and functional features of clasts in low phosphate, vitamin D-deficiency rickets. Calcif Tissue Int 67:400407.
  • Nordsletten L, Kaastad TS, Skjeldal S, Kirkeby OJ, Reikeras O, Ekeland A. (1993) Training increases the in vivo strength of the lower leg: an experimental study in the rat. J Bone Miner Res 8:10891095.
  • Nordsletten L, Kaastad TS, Madsen JE, Reikeras O, Ovstebo R, Stromme JH, Falch J. (1994) The development of femoral osteopenia in ovariectomized rats is not reduced by high intensity treadmill training: a mechanical and densitometric study. Calcif Tissue Int 55:436442.
  • Ohta T, Wergedal JE, Gruber HE, Baylink DJ, Lau KH. (1995) Low dose phenytoin is an osteogenic agent in the rat. Calcif Tissue Int 56:4248.
  • Oner N, Kaya M, Karasalihoglu S, Karaca H, Celtik C, Tutunculer F. (2004) Bone mineral metabolism changes in epileptic children receiving valproic acid. J Paediatr Child Health 40:470473.
  • Onodera K, Takahashi A, Mayanagi H, Wakabayashi H, Kamei J, Shinoda H. (2001) Phenytoin-induced bone loss and its prevention with alfacalcidol or calcitriol in growing rats. Calcif Tissue Int 69:109116.
  • Onodera K, Takahashi A, Wakabayashi H, Kamei J, Sakurada S. (2003) Effects of menatetrenone on the bone and serum levels of vitamin K2 (menaquinone derivatives) in osteopenia induced by phenytoin in growing rats. Nutrition 19:446450.
  • Pack AM. (2003) The association between antiepileptic drugs and bone disease. Epilepsy Currents 3:9195.
  • Pack AM, Morrell MJ. (2004) Epilepsy and bone health in adults. Epilepsy & Behaviour 2 5 Suppl:S24S29.
  • Pack AM, Morrell MJ, Marcus R, Holloway L, Flaster E, Done S, Randall A, Seale C, Shane E. (2005) Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol 57:252257.
  • Raisz LG. (2005) Pathogenesis of osteoporosis: concepts, conflicts, and prospects. The Journal of Clinical Investigation 115:33183325.
  • Ratnaraj N, Doheny HC, Patsalos PN. (1996) A micromethod for the determination of the new antiepileptic drug levetiracetam (ucb LO59) in serum or plasma by high performance liquid chromatography. Ther Drug Monit 18:154157.
  • Rieger-Wettengl G, Tutlewski B, Stabrey A, Rauch F, Herkenrath P, Schauseil-Zipf U, Schoenau E. (2001) Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine. Pediatrics 108:E107.
  • Robinson PB, Harris M, Harvey W, Papadogeorgakis N. (1982) Reduced Bone-Growth in Rats Treated with Anti-Convulsant Drugs – A Type-II Pseudohypoparathyroidism. Metabolic Bone Disease & Related Research 4:269275.
  • Sato Y, Kondo I, Ishida S, Motooka H, Takayama K, Tomita Y, Maeda H, Satoh K. (2001) Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology 57:445449.
  • Schapira D, Linn S, Sarid M, Mokadi S, Kabala A, Silbermann M. (1995) Calcium and vitamin D enriched diets increase and preserve vertebral mineral content in aging laboratory rats. Bone 16:575582.
  • Schroeder TM, Westendorf JJ. (2005) Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res 20:22542263.
  • Seeman E. (1997) From density to structure: growing up and growing old on the surfaces of bone. J Bone Miner Res 12:509521.
  • Souverein PC, Webb DJ, Weil JG, Van Staa TP, Egberts AC. (2006) Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy. Neurology 66:13181324.
  • Svalheim S, Taubøll E, Dahl E, Aleksandersen M, McNeilly A, Ropstad E, Gjerstad L. (2005) Levetiracetam affects gonadotropin levels and peripheral sex steroid hormones in female Wistar rats. Epilepsia 46:189 (abstract).
  • Takahashi A, Onodera K, Shinoda H, Mayanagi H. (2000) Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria. Jpn J Pharmacol 82:8284.
  • Takahashi A, Saito T, Mayanagi H, Kamei J, Onodera K. (2004) Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats. Methods Find Exp Clin Pharmacol 26:769773.
  • Taubøll E, Svalheim S, Surdova K, Ormel L, Alexandersen M, Gjerstad L. (2004) Long-term levetiracetam treatment affects ovary size and morphology in female Wistar rats. Epilepsia 45(suppl 7):129130 (abstract).
  • Taubøll E, Gregoraszczuk EL, Tworzydo A, Wojtowicz AK, Ropstad E. (2006) Comparison of Reproductive Effects of Levetiracetam and Valproate Studied in Prepubertal Porcine Ovarian Follicular Cells. Epilepsia 47:15801583.
  • Tsukahara H, Kimura K, Todoroki Y, Ohshima Y, Hiraoka M, Shigematsu Y, Tsukahara Y, Miura M, Mayumi M. (2002) Bone mineral status in ambulatory pediatric patients on long-term anti-epileptic drug therapy. Pediatr Int 44:247253.
  • Turner CH. (2002) Biomechanics of bone: determinants of skeletal fragility and bone quality. Osteoporos Int 13:97104.
  • Valimaki MJ, Tiihonen M, Laitinen K, Tahtela R, Karkkainen M, Lamberg-Allardt C, Makela P, Tunninen R. (1994) Bone mineral density measured by dual-energy x-ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs. J Bone Miner Res 9:631637.
  • Vestergaard P. (2005) Epilepsy, osteoporosis and fracture risk – a meta-analysis. Acta Neurol Scand 112:277286.