Psychiatric Comorbidity in Epilepsy: A Population-Based Analysis
Article first published online: 28 JUL 2007
Volume 48, Issue 12, pages 2336–2344, December 2007
How to Cite
Tellez-Zenteno, J. F., Patten, S. B., Jetté, N., Williams, J. and Wiebe, S. (2007), Psychiatric Comorbidity in Epilepsy: A Population-Based Analysis. Epilepsia, 48: 2336–2344. doi: 10.1111/j.1528-1167.2007.01222.x
- Issue published online: 5 OCT 2007
- Article first published online: 28 JUL 2007
- Accepted May 21, 2007; Online Early publication July 30, 2007.
- Psychiatric comorbidity;
- Anxiety disorders;
- Mood disorders;
- Substance abuse;
- Suicidal ideation;
- Health surveys;
Purpose: The estimated prevalence of mental health disorders in those with epilepsy in the general population varies owing to differences in study methods and heterogeneity of epilepsy syndromes. We assessed the population-based prevalence of various psychiatric conditions associated with epilepsy using a large Canadian national population health survey.
Methods: The Canadian Community Health Survey (CCHS 1.2) was used to explore numerous aspects of mental health in persons with epilepsy in the community compared with those without epilepsy. The CCHS includes administration of the World Mental Health Composite International Diagnostic Interview to a sample of 36,984 subjects. Age-specific prevalence of mental health conditions in epilepsy was assessed using logistic regression.
Results: The prevalence of epilepsy was 0.6%. Individuals with epilepsy were more likely than individuals without epilepsy to report lifetime anxiety disorders or suicidal thoughts with odds ratio of 2.4 (95% CI = 1.5–3.8) and 2.2 (1.4–3.3), respectively. In the crude analysis, the odds of lifetime major depression or panic disorder/agoraphobia were not greater in those with epilepsy than those without epilepsy, but the association with lifetime major depression became significant after adjustment for covariates.
Conclusions: In the community, epilepsy is associated with an increased prevalence of mental health disorders compared with the general population. Epilepsy is also associated with a higher prevalence of suicidal ideation. Understanding the psychiatric correlates of epilepsy is important to adequately manage this patient population.