Presented as part of the AES Annual Course: Problems for People with Epilepsy Beyond Seizures, December 2, 2006, San Diego, CA.
The basic science of memory as it applies to epilepsy
Version of Record online: 29 NOV 2007
Volume 48, Issue Supplement s9, pages 23–25, December 2007
How to Cite
Meador, K. J. (2007), The basic science of memory as it applies to epilepsy. Epilepsia, 48: 23–25. doi: 10.1111/j.1528-1167.2007.01396.x
- Issue online: 29 NOV 2007
- Version of Record online: 29 NOV 2007
- Cellular and molecular mechanism;
- Long-term potentiation;
- Synaptic activity
Summary The mechanisms of memory delineated by the model of long-term potentiation (LTP) are similar to those underlying epileptogenesis by kindling. Memory is impaired by seizures and epilepsy. High frequency neural activity is important in both memory formation and seizures. Both kindling and LTP are most effectively induced by high-frequency stimuli, involve synaptic facilitation, and share overlapping molecular mechanisms, such as N-methyl-d-aspartate (NMDA) receptor-induced calcium cascade and protein synthesis. The hippocampus contributes to both through its role in memory formation and its low seizure threshold.