Adiponectin and visfatin concentrations in children treated with valproic acid
Article first published online: 7 DEC 2007
2008 International League Against Epilepsy
Volume 49, Issue 2, pages 353–357, February 2008
How to Cite
Rauchenzauner, M., Haberlandt, E., Scholl-Bürgi, S., Ernst, B., Hoppichler, F., Karall, D., Ebenbichler, C. F., Rostasy, K. and Luef, G. (2008), Adiponectin and visfatin concentrations in children treated with valproic acid. Epilepsia, 49: 353–357. doi: 10.1111/j.1528-1167.2007.01460.x
- Issue published online: 7 DEC 2007
- Article first published online: 7 DEC 2007
- Accepted October 25, 2007; Online Early publication December 10, 2007.
Chronic antiepileptic therapy with valproic acid (VPA) is associated with increased body weight and insulin resistance in adults and children. Attempts to determine the underlying pathophysiologic mechanisms have failed. Adipocytokines have recently been defined as a link between glucose and fat metabolism. We herein demonstrate that VPA-associated overweight is accompanied by lower adiponectin and higher leptin concentrations in children. The absence of any relationship with visfatin concentration does not suggest a role of this novel insulin-mimetic hormone in VPA-associated metabolic alterations. Therefore, adiponectin and leptin but not visfatin may be considered as potential regulators of glucose and fat metabolism during VPA-therapy.