1528-1167/asset/olbannerleft.gif?v=1&s=bae5cfdb8dec65198cd267c78826e3fef2ef0ede)
Seizures following picornavirus infection
Article first published online: 6 MAR 2008
DOI: 10.1111/j.1528-1167.2008.01535.x
© 2008 International League Against Epilepsy
Additional Information
How to Cite
Libbey, J. E., Kirkman, N. J., Smith, M. C., Tanaka, T., Wilcox, K. S., White, H. S. and Fujinami, R. S. (2008), Seizures following picornavirus infection. Epilepsia, 49: 1066–1074. doi: 10.1111/j.1528-1167.2008.01535.x
Publication History
- Issue published online: 6 MAR 2008
- Article first published online: 6 MAR 2008
- Accepted January 6, 2008; Online Early publication March 6, 2008.
- Abstract
- Article
- References
- Cited By
Keywords:
- Theiler's murine encephalomyelitis virus;
- Seizures;
- Epilepsy
Summary
Purpose: We demonstrate the establishment and characterization of a novel virus infection-induced seizure model in C57BL/6 mice.
Methods: C57BL/6 mice were infected with Theiler's murine encephalomyelitis virus (TMEV) or mock infected. Mice were followed for seizures, weight change, body temperature, motor function (righting reflex, rotorod) and neurological manifestations (inflammation [perivascular cuffing], pyknotic neurons, transforming growth factor [TGF]-β expression).
Results: C57BL/6 mice are susceptible to seizures induced by TMEV infection. Approximately 50% of C57BL/6 mice develop transient afebrile seizures. Motor function and coordination are impaired in seized mice. Pyramidal neuron pyknosis and TGF-β expression correlate with seizure activity in the hippocampus.
Discussion: The characterization of this model will enable the investigation of viral and immune contributions in the central nervous system to the development of seizure disorders in humans.