Structural changes for adult-born dentate granule cells after status epilepticus

Authors


‡Current address: Institute of Cell Biology, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland.

Address correspondence to Dr. Charles E. Ribak, Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, CA 92697-1275, U.S.A. E-mail: ribak@uci.edu

Summary

Status epilepticus (SE) not only results in an increased number of newly generated neurons in the dentate gyrus but also leads to structural alterations of many of these newborn granule cells. One of the structural changes involving newly generated dentate granule cells is the formation of hilar basal dendrites that persist on mature granule cells and integrate into synaptic circuitry. SE also causes other newborn granule cells to migrate ectopically into the hilus, and these cells also integrate into synaptic circuitry. This article will describe these structural alterations of granule cells found in the dentate gyrus after SE and will also discuss the time course of these events and possible underlying causes.

Ancillary