History of simple febrile seizures is associated with hippocampal abnormalities in adults
Article first published online: 22 MAY 2008
© 2008 International League Against Epilepsy
Volume 49, Issue 9, pages 1562–1569, September 2008
How to Cite
Auer, T., Barsi, P., Bone, B., Angyalosi, A., Aradi, M., Szalay, C., Horvath, R. A., Kovacs, N., Kotek, G., Fogarasi, A., Komoly, S., Janszky, I., Schwarcz, A. and Janszky, J. (2008), History of simple febrile seizures is associated with hippocampal abnormalities in adults. Epilepsia, 49: 1562–1569. doi: 10.1111/j.1528-1167.2008.01679.x
- Issue published online: 3 SEP 2008
- Article first published online: 22 MAY 2008
- Accepted April 17, 2008; Early View publication May 22, 2008.
- Mesial temporal lobe epilepsy;
- Simple febrile convulsions;
- Hippocampal sclerosis;
- Gender differences;
- MRI volumetry
Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults>15 years after a simple FS.
Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS– group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements.
Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3in the FS+ group and 6.63 ± 1.46 cm3in the FS– group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3in the FS+ men and 4.05 ± 0.48 cm3in the FS– men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3in the FS+ men and 7.48 ± 1.14 cm3in the FS– men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection.
Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.