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Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets

  1. Thomas N. Seyfried,
  2. Michael Kiebish,
  3. Purna Mukherjee,
  4. Jeremy Marsh

Article first published online: 4 NOV 2008

DOI: 10.1111/j.1528-1167.2008.01853.x

Issue

Epilepsia

Epilepsia

Special Issue: Ketogenic Diet and Related Dietary Treatments

Volume 49, Issue Supplement s8, pages 114–116, November 2008

Additional Information

How to Cite

Seyfried, T. N., Kiebish, M., Mukherjee, P. and Marsh, J. (2008), Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets. Epilepsia, 49: 114–116. doi: 10.1111/j.1528-1167.2008.01853.x

Author Information

  1. Department of Biology, Boston College, Chestnut Hill, Massachusetts, U.S.A

*Address correspondence to Thomas N. Seyfried, Department of Biology, Boston College, Chestnut Hill, MA 02467, U.S.A. E-mail: thomas.seyfried@bc.edu

Publication History

  1. Issue published online: 4 NOV 2008
  2. Article first published online: 4 NOV 2008

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Keywords:

  • Glioma;
  • Vascularity;
  • Caloric restriction;
  • Ketone bodies;
  • Metabolic control analysis;
  • Angiogenesis;
  • Apoptosis;
  • Inflammation

Summary

Information is presented on the calorically restricted ketogenic diet (CRKD) as an alternative therapy for brain cancer. In contrast to normal neurons and glia, which evolved to metabolize ketone bodies as an alternative fuel to glucose under energy-restricted conditions, brain tumor cells are largely glycolytic due to mitochondrial defects and have a reduced ability to metabolize ketone bodies. The CRKD is effective in managing brain tumor growth in animal models and in patients, and appears to act through antiangiogenic, anti-inflammatory, and proapoptotic mechanisms.

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