Ictal hypoventilation contributes to cardiac arrhythmia and SUDEP: Report on two deaths in video-EEG–monitored patients
Version of Record online: 3 FEB 2010
Wiley Periodicals, Inc. © 2010 International League Against Epilepsy
Volume 51, Issue 5, pages 916–920, May 2010
How to Cite
Bateman, L. M., Spitz, M. and Seyal, M. (2010), Ictal hypoventilation contributes to cardiac arrhythmia and SUDEP: Report on two deaths in video-EEG–monitored patients. Epilepsia, 51: 916–920. doi: 10.1111/j.1528-1167.2009.02513.x
- Issue online: 22 APR 2010
- Version of Record online: 3 FEB 2010
- Accepted December 10, 2009; Early View publication February 3, 2010.
- Sudden unexpected death in epilepsy;
- Epilepsy monitoring unit;
Sudden unexplained death in epilepsy (SUDEP) is a common cause of death in patients with epilepsy, with cardiorespiratory dysfunction and a primary cessation of cerebral function proposed as causes. We report two cases of SUDEP in patients with intractable temporal lobe epilepsy undergoing video-EEG (electroencephalography) telemetry at two centers. Both had secondarily generalized convulsions. EEG, electrocardiography (ECG), and respiratory changes in these two patients are reported herein. Ictal/postictal hypoventilation may contribute to SUDEP with the resulting hypoxemia and acidosis leading to failure of recovery of cortical function and eventual cardiac failure.