A ketogenic diet does not impair rat behavior or long-term potentiation
Article first published online: 3 FEB 2010
Wiley Periodicals, Inc. © 2010 International League Against Epilepsy
Volume 51, Issue 8, pages 1619–1623, August 2010
How to Cite
Thio, L. L., Rensing, N., Maloney, S., Wozniak, D. F., Xiong, C. and Yamada, K. A. (2010), A ketogenic diet does not impair rat behavior or long-term potentiation. Epilepsia, 51: 1619–1623. doi: 10.1111/j.1528-1167.2009.02515.x
- Issue published online: 5 AUG 2010
- Article first published online: 3 FEB 2010
- Accepted December 14, 2009; Early View publication February 3, 2010.
- Conditioned fear test;
- Locomotor activity;
- Medial perforant path;
- Paired-pulse modulation
The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically. We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.