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Figure S1. KD fed rats show slower weight gain and higher serum βHB concentrations. (A) Mean body weight versus age for rats fed a SD (n = 3–12), KD (n = 5–12), or CR diet (n = 4–12). n is given as a range because some rats were not weighed at every time point. Some of these rats were used in the experiments shown in Figs. 1and 2. (B) Mean serum βHB concentrations in rats fed a SD (n = 4), KD (n = 4), or CR (n = 5) for 2 weeks. *p < 0.05 versus SD and CR by one-way ANOVA.

Figure S2. KD fed and CR rats do not exhibit altered in vivo medial perforant path LTP as assessed by PS amplitude (A) or the slope of the second fEPSP of a pair of fEPSPs (B). Mean PS amplitude or the mean slope of the second fEPSP of a pair of fEPSPs before and after a 1 s 100 Hz tetanus (arrow) in rats fed a SD (n = 7), a KD (n = 7), or a CR diet (n = 7). Pairs of fEPSPs were evoked at an interval of 20 ms. Data are from the same animals as in Fig. 2.

Data S1. Supplementary Methods.

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EPI_2515_sm_KDLTP2-2SupportingInfo-Methods.doc74KSupporting info item
EPI_2515_sm_KDLTP2-4SupporitngInfo-Figures.doc407KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.