Figure S1. Final population PK model.

Table S1. Summary of trial data included in the PK-PD analysis.

Table S2. Parameter values from the final population pharmacokinetic model.

Table S3. Validation of the final model and evaluation of age effect for time to first seizure after randomization end point with topiramate monotherapy.

Table S4. Validation of the final model for the responder rate end point in adjunctive therapy.

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