The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway
Article first published online: 3 MAR 2011
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy
Volume 52, Issue 3, pages e7–e11, March 2011
How to Cite
McDaniel, S. S., Rensing, N. R., Thio, L. L., Yamada, K. A. and Wong, M. (2011), The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia, 52: e7–e11. doi: 10.1111/j.1528-1167.2011.02981.x
- Issue published online: 11 MAR 2011
- Article first published online: 3 MAR 2011
- Accepted December 27, 2010; Early View publication March 3, 2011.
The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition.