FULL-LENGTH ORIGINAL RESEARCH
Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures
Article first published online: 2 MAR 2011
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy
Volume 52, Issue 4, pages 753–765, April 2011
How to Cite
Rakhade, S. N., Klein, P. M., Huynh, T., Hilario-Gomez, C., Kosaras, B., Rotenberg, A. and Jensen, F. E. (2011), Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures. Epilepsia, 52: 753–765. doi: 10.1111/j.1528-1167.2011.02992.x
- Issue published online: 4 APR 2011
- Article first published online: 2 MAR 2011
- Accepted January 7, 2011; Early View publication March 2, 2011.
Data S1. Methods.
Figure S1. Representative EEG recording from P10 rat pups before and during hypoxia obtained using subdermal wire electrodes.
Figure S2. Survey view of Fluoro-Jade B staining following hypoxia-induced neonatal seizures and following unilateral infarct after unilateral carotid artery ligation.
Figure S3. Calculation of seizure frequency in animals that have experienced neonatal seizures using graded duration criteria for definition of spontaneous seizures.
Table S1. Comparison of characteristics of normal cortical rhythms, interictal spikes, and spike wave seizures observed in adult Long-Evans rats.
Video S1. Representative video-EEG from P10 rat pup experiencing neonatal seizures on exposure to graded global hypoxia.
Video S2. Representative video-EEG from adult rat showing behavior associated with epileptic seizures—video-EEG recording from an adult Long-Evans rat that had experienced neonatal seizures at P10 shows the onset of spontaneous seizure activity.
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