Evaluation of brain connectivity: The role of magnetoencephalography


Address Correspondence to Richard C. Burgess, M.D., Ph.D., Epilepsy Center, Cleveland Clinic Foundation, Mail Code S51, 9500 Euclid Avenue, Cleveland, OH 44195, U.S.A. E-mail: rcb@eeg.ccf.org


Communication between regions of the brain, both normal interactions and pathologic traffic, is manifest by electromagnetic activity. Magnetoencephalography (MEG)—with high resolution in both the temporal and spatial domains, as well as a comprehensive, whole-head view—offers ready noninvasive access to this ongoing communication. The waveforms are amenable to a variety of signal processing techniques that can elucidate connectivity between brain areas. In conjunction with the other modalities acquired during the evaluation of a patient with epilepsy, MEG can provide information that is important for determining therapeutic strategy.