Acute-onset epilepsy triggered by fever mimicking FIRES (febrile infection–related epilepsy syndrome): The role of protocadherin 19 (PCDH19) gene mutation
Article first published online: 21 JUL 2011
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy
Volume 52, Issue 11, pages e172–e175, November 2011
How to Cite
Specchio, N., Fusco, L. and Vigevano, F. (2011), Acute-onset epilepsy triggered by fever mimicking FIRES (febrile infection–related epilepsy syndrome): The role of protocadherin 19 (PCDH19) gene mutation. Epilepsia, 52: e172–e175. doi: 10.1111/j.1528-1167.2011.03193.x
- Issue published online: 27 OCT 2011
- Article first published online: 21 JUL 2011
- Accepted June 8, 2011; Early View publication July 21, 2011.
- Acute onset epilepsy;
- Febrile onset;
To report differences and similarities between febrile infection–related epilepsy syndrome (FIRES) and epilepsy in female patients with protocadherin 19 (PCDH19) mutation. These are two recently described epileptic conditions characterized by drug-resistant epilepsy and cognitive impairment. We report, as exemplification, one of our patients with acute-onset epilepsy triggered by fever with clinical course resembling FIRES, but with a missense mutation of PCDH19 gene. The clinical characteristics of this patient are similar to those reported for FIRES. We believe that female patients with febrile acute-onset epilepsy resembling FIRES are potential PCDH19 mutation carriers.