FUTURE PERSPECTIVES, NOVEL THERAPY, AND INNOVATION
What is the value of hypothermia in acute neurologic diseases and status epilepticus?
Article first published online: 3 OCT 2011
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy
Special Issue: Proceedings of the 3rd London-Innsbruck Colloquium on Acute Seizures and Status Epilepticus
Volume 52, Issue Supplement s8, pages 64–66, October 2011
How to Cite
Rossetti, A. O. (2011), What is the value of hypothermia in acute neurologic diseases and status epilepticus?. Epilepsia, 52: 64–66. doi: 10.1111/j.1528-1167.2011.03241.x
- Issue published online: 3 OCT 2011
- Article first published online: 3 OCT 2011
Patients with status epilepticus that proves refractory to anesthetic agents represent a daunting challenge for treating clinicians. Animal data support the neuroprotective action of brain hypothermia, and its efficacy in status epilepticus models. This approach, targeting a core temperature of about 33°C for at least 24 hours together with pharmacological sedation, has been described in adults and children. However, although relatively safe if concomitant barbiturates are avoided, it seems that mild hypothermia rarely allows a sustained control of ongoing status epilepticus, since seizures tend to recur in normothermia. Conversely, mild hypothermia has a high-evidence level and is increasingly used in postanoxic encephalopathy, both in newborns and adults. Due to the paucity of available clinical data, prospective studies are needed to assess the value of hypothermia in status epilepticus.