FULL-LENGTH ORIGINAL RESEARCH
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage
Article first published online: 9 DEC 2011
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy
Volume 53, Issue 1, pages 134–146, January 2012
How to Cite
White, H. S., Alex, A. B., Pollock, A., Hen, N., Shekh-Ahmad, T., Wilcox, K. S., McDonough, J. H., Stables, J. P., Kaufmann, D., Yagen, B. and Bialer, M. (2012), A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia, 53: 134–146. doi: 10.1111/j.1528-1167.2011.03338.x
- Issue published online: 4 JAN 2012
- Article first published online: 9 DEC 2011
- Accepted October 17, 2011; Early View publication December 9, 2011.
Vol. 53, Issue 2, 397, Article first published online: 26 JAN 2012
Data S1. Experimental section: Materials and methods.
Figure S1. Plasma concentration-time plot obtained following intraperitoneal administration of SPD (60 mg/kg) to rats.
Table S1. Effect of SPD on the threshold for minimal seizures induced by the timed intravenous infusion of Metrazol in mice following intraperitoneal administration.
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