CRITICAL REVIEW AND INVITED COMMENTARY
Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms
Version of Record online: 22 DEC 2011
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy
Volume 53, Issue 1, pages 7–15, January 2012
How to Cite
Quigg, M., Rolston, J. and Barbaro, N. M. (2012), Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms. Epilepsia, 53: 7–15. doi: 10.1111/j.1528-1167.2011.03339.x
- Issue online: 4 JAN 2012
- Version of Record online: 22 DEC 2011
- Accepted October 17, 2011; Early View publication December 22, 2011.
- Mesial temporal lobe epilepsy;
- Epilepsy surgery;
- Gamma Knife;
- Partial seizure
Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway.