Seizures and epilepsy in Sotos syndrome: Analysis of 19 Caucasian patients with long-term follow-up
Article first published online: 21 FEB 2012
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
Volume 53, Issue 6, pages e102–e105, June 2012
How to Cite
Nicita, F., Ruggieri, M., Polizzi, A., Mauceri, L., Salpietro, V., Briuglia, S., Papetti, L., Ursitti, F., Grosso, S., Tarani, L., Segni, M., Savasta, S., Parisi, P., Verrotti, A. and Spalice, A. (2012), Seizures and epilepsy in Sotos syndrome: Analysis of 19 Caucasian patients with long-term follow-up. Epilepsia, 53: e102–e105. doi: 10.1111/j.1528-1167.2012.03418.x
- Issue published online: 1 JUN 2012
- Article first published online: 21 FEB 2012
- Accepted January 10, 2012; Early View publication February 21, 2012.
- Sotos syndrome;
- Cerebral gigantism;
- Overgrowth syndrome
Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9–50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies have investigated the electroclinical features and the long-term outcome in epileptic SS patients. The authors report a series of 19 SS patients with FS and/or epilepsy during childhood and a long-term follow-up. More than half of FS evolved to epilepsy. Temporal lobe seizures were recorded in 40% of patients with SS. Seizures were easy to control with common antiepileptic drugs in almost all patients. A careful neurologic evaluation is useful for SS patients, since seizures are an important finding among people with this overgrowth syndrome.