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  • Akamizu T, Takaya K, Irako T, Hosoda H, Teramukai S, Matsuyama A, Tada H, Miura K, Shimizu A, Fukushima M, Yokode M, Tanaka K, Kangawa K. (2004) Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol 150:447455.
  • Angelidis G, Valotassiou V, Georgoulias P. (2010) Current and potential roles of ghrelin in clinical practice. J Endocrinol Invest 33:823838.
  • Aslan A, Yildirim M, Ayyildiz M, Guven A, Agar E. (2009) The role of nitric oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform activity in rat. Neuropeptides 43:295302.
  • Ataie Z, Golzar MG, Babri S, Ebrahimi H, Mohaddes G. (2011) Does ghrelin level change after epileptic seizure in rats? Seizure 20:347349.
  • Aydin S, Dag E, Ozkan Y, Erman F, Dagli AF, Kilic N, Sahin I, Karatas F, Yoldas T, Barim AO, Kendir Y. (2009) Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders. Mol Cell Biochem 328:4956.
  • Aydin S, Dag E, Ozkan Y, Arslan O, Koc G, Bek S, Kirbas S, Kasikci T, Abasli D, Gokcil Z, Odabasi Z, Catak Z. (2011) Time-dependent changes in the serum levels of prolactin, nesfatin-1 and ghrelin as a marker of epileptic attacks young male patients. Peptides 32:12761280.
  • Baatar D, Patel K, Taub DD. (2011) The effects of ghrelin on inflammation and the immune system. Mol Cell Endocrinol 340:4458.
  • Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T. (2005) Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides 39:249251.
  • Banks WA, Tschop M, Robinson SM, Heiman ML. (2002) Extent and direction of ghrelin transport across the blood–brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302:822827.
  • Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Krock L, Rebek J Jr. (2004) Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A 101:1047010475.
  • Beck H, Goussakov IV, Lie A, Helmstaedter C, Elger CE. (2000) Synaptic plasticity in the human dentate gyrus. J Neurosci 20:70807086.
  • Ben-Ari Y, Crepel V, Represa A. (2008) Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses. Epilepsy Curr 8:6872.
  • Berilgen MS, Mungen B, Ustundag B, Demir C. (2006) Serum ghrelin levels are enhanced in patients with epilepsy. Seizure 15:106111.
  • Biagini G, Torsello A, Marinelli C, Gualtieri F, Vezzali R, Coco S, Bresciani E, Locatelli V. (2011) Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. Eur J Pharmacol 670:130136.
  • Bielohuby M, Sawitzky M, Stoehr BJ, Stock P, Menhofer D, Ebensing S, Bjerre M, Frystyk J, Binder G, Strasburger C, Wu Z, Christ B, Hoeflich A, Bidlingmaier M. (2011) Lack of dietary carbohydrates induces hepatic growth hormone (GH) resistance in rats. Endocrinology 152:19481960.
  • Bliss TV, Collingridge GL. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:3139.
  • Camina JP. (2006) Cell biology of the ghrelin receptor. J Neuroendocrinol 18:6576.
  • Caminos JE, Gualillo O, Lago F, Otero M, Blanco M, Gallego R, Garcia-Caballero T, Goldring MB, Casanueva FF, Gomez-Reino JJ, Dieguez C. (2005) The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes. Endocrinology 146:12851292.
  • Cansu A, Serdaroglu A, Camurdan O, Hirfanoglu T, Cinaz P. (2011a) Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate. Horm Res Paediatr 76:6571.
  • Cansu A, Serdaroglu A, Cinaz P. (2011b) Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving oxcarbazepine. Eur J Paediatr Neurol 15:527531.
  • Carlini VP, Monzon ME, Varas MM, Cragnolini AB, Schioth HB, Scimonelli TN, de Barioglio SR. (2002) Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem Biophys Res Commun 299:739743.
  • Chen L, Xing T, Wang M, Miao Y, Tang M, Chen J, Li G, Ruan DY. (2011) Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats. Eur J Neurosci 33:266275.
  • Cheyuo C, Wu R, Zhou M, Jacob A, Coppa G, Wang P. (2011) Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve. Shock 35:258265.
  • Chu KM, Chow KB, Leung PK, Lau PN, Chan CB, Cheng CH, Wise H. (2007) Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity. Int J Biochem Cell Biol 39:752764.
  • Chung H, Seo S, Moon M, Park S. (2008) Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. J Endocrinol 198:511521.
  • Cifelli P, Grace AA. (2011) Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity. Int J Neuropsychopharmacol July 12 [Epub ahead of print].
  • Coumis U, Davies CH. (2002) The effects of galanin on long-term synaptic plasticity in the CA1 area of rodent hippocampus. Neuroscience 112:173182.
  • Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649661.
  • Dag E, Aydin S, Ozkan Y, Erman F, Dagli AF, Gurger M. (2010) Alteration in chromogranin A, obestatin and total ghrelin levels of saliva and serum in epilepsy cases. Peptides 31:932937.
  • Delhanty PJ, van Koetsveld PM, Gauna C, van de Zande B, Vitale G, Hofland LJ, van der Lely AJ. (2007) Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway. Am J Physiol Endocrinol Metab 293:E302E309.
  • Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschop MH, Horvath TL. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9:381388.
  • Ferraro G, Sardo P. (2004) Nitric oxide and brain hyperexcitability. In Vivo 18:357366.
  • Ferrini F, Salio C, Lossi L, Merighi A. (2009) Ghrelin in central neurons. Curr Neuropharmacol 7:3749.
  • Filigheddu N, Gnocchi VF, Coscia M, Cappelli M, Porporato PE, Taulli R, Traini S, Baldanzi G, Chianale F, Cutrupi S, Arnoletti E, Ghe C, Fubini A, Surico N, Sinigaglia F, Ponzetto C, Muccioli G, Crepaldi T, Graziani A. (2007) Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells. Mol Biol Cell 18:986994.
  • Gaskin FS, Farr SA, Banks WA, Kumar VB, Morley JE. (2003) Ghrelin-induced feeding is dependent on nitric oxide. Peptides 24:913918.
  • Ghigo E, Broglio F, Arvat E, Maccario M, Papotti M, Muccioli G. (2005) Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol (Oxf) 62:117.
  • Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghe C, Isgaard J, Papotti M, Ghigo E, Muccioli G. (2007) Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling. Endocrinology 148:512529.
  • Greco R, Latini G, Chiarelli F, Iannetti P, Verrotti A. (2005) Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid. Neurology 65:18081809.
  • Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. (2010) Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities. J Pept Sci 16:486495.
  • Gungor S, Yucel G, Akinci A, Tabel Y, Ozerol IH, Yologlu S. (2007) The role of ghrelin in weight gain and growth in epileptic children using valproate. J Child Neurol 22:13841388.
  • Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE. (2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A 105:63206325.
  • Hokfelt T, Bartfai T, Bloom F. (2003) Neuropeptides: opportunities for drug discovery. Lancet Neurol 2:463472.
  • Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. (2003) High constitutive signaling of the ghrelin receptor – identification of a potent inverse agonist. Mol Endocrinol 17:22012210.
  • Honors MA, Davenport BM, Kinzig KP. (2009) Effects of consuming a high carbohydrate diet after eight weeks of exposure to a ketogenic diet. Nutr Metab (Lond) 6:46.
  • Iglesias MJ, Pineiro R, Blanco M, Gallego R, Dieguez C, Gualillo O, Gonzalez-Juanatey JR, Lago F. (2004) Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes. Cardiovasc Res 62:481488.
  • Jerlhag E, Egecioglu E, Dickson SL, Andersson M, Svensson L, Engel JA. (2006) Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict Biol 11:4554.
  • Jiang H, Betancourt L, Smith RG. (2006) Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol 20:17721785.
  • Kluge C, Stoppel C, Szinyei C, Stork O, Pape HC. (2008) Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity. Learn Mem 15:252260.
  • Kojima M. (2008) The discovery of ghrelin – a personal memory. Regul Pept 145:26.
  • Kojima M, Kangawa K. (2005) Ghrelin: structure and function. Physiol Rev 85:495522.
  • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656660.
  • Lamirault L, Guillou JL, Micheau J, Jaffard R. (2001) Intrahippocampal injections of somatostatin dissociate acquisition from the flexible use of place responses. Eur J Neurosci 14:567570.
  • Lear PV, Iglesias MJ, Feijoo-Bandin S, Rodriguez-Penas D, Mosquera-Leal A, Garcia-Rua V, Gualillo O, Ghe C, Arnoletti E, Muccioli G, Dieguez C, Gonzalez-Juanatey JR, Lago F. (2010) Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes. Endocrinology 151:32863298.
  • Lee J, Lim E, Kim Y, Li E, Park S. (2010) Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Endocrinol 205:263270.
  • Lehmann TN, Gabriel S, Kovacs R, Eilers A, Kivi A, Schulze K, Lanksch WR, Meencke HJ, Heinemann U. (2000) Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats. Epilepsia 41(Suppl. 6):S190S194.
  • Leung PK, Chow KB, Lau PN, Chu KM, Chan CB, Cheng CH, Wise H. (2007) The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cell Signal 19:10111022.
  • Lim CT, Kola B, Korbonits M. (2011) The ghrelin/GOAT/GHS-R system and energy metabolism. Rev Endocr Metab Disord 12:173186.
  • Lopez NE, Krzyzaniak MJ, Blow C, Putnam J, Ortiz-Pomales Y, Hageny AM, Eliceiri B, Coimbra R, Bansal V. (2012) Ghrelin prevents disruption of the blood–brain barrier after traumatic brain injury. J Neurotrauma 29:385393.
  • Lu X, Roberts E, Xia F, Sanchez-Alavez M, Liu T, Baldwin R, Wu S, Chang J, Wasterlain CG, Bartfai T. (2010) GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A 107:1522915234.
  • MacLean CM, Casanova AT, Baselgia-Jeker L, Neave N, Larsen F, Skillern L, Drewe J, Beglinger C. (2009) Effect of food on the pharmacokinetics and pharmacodynamics of an oral ghrelin agonist (ARD-07) in healthy subjects. J Clin Pharmacol 49:553559.
  • Mazarati A, Wasterlain CG. (2002) Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus. Neurosci Lett 331:123127.
  • Nishi Y, Hiejima H, Mifune H, Sato T, Kangawa K, Kojima M. (2005) Developmental changes in the pattern of ghrelin’s acyl modification and the levels of acyl-modified ghrelins in murine stomach. Endocrinology 146:27092715.
  • Noe F, Vaghi V, Balducci C, Fitzsimons H, Bland R, Zardoni D, Sperk G, Carli M, During MJ, Vezzani A. (2010) Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus. Gene Ther 17:643652.
  • Obay BD, Tasdemir E, Tumer C, Bilgin HM, Sermet A. (2007) Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides 28:12141219.
  • Obay BD, Tasdemir E, Tumer C, Bilgin HM, Atmaca M. (2008) Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model. Peptides 29:448455.
  • Ogren SO, Kuteeva E, Elvander-Tottie E, Hokfelt T. (2010) Neuropeptides in learning and memory processes with focus on galanin. Eur J Pharmacol 626:917.
  • Olsson C, Holbrook JD, Bompadre G, Jonsson E, Hoyle CH, Sanger GJ, Holmgren S, Andrews PL. (2008) Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. Gen Comp Endocrinol 155:217226.
  • Pantel J, Legendre M, Cabrol S, Hilal L, Hajaji Y, Morisset S, Nivot S, Vie-Luton MP, Grouselle D, de Kerdanet M, Kadiri A, Epelbaum J, Le Bouc Y, Amselem S. (2006) Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. J Clin Invest 116:760768.
  • Petersen PS, Woldbye DP, Madsen AN, Egerod KL, Jin C, Lang M, Rasmussen M, Beck-Sickinger AG, Holst B. (2009) In vivo characterization of high basal signaling from the ghrelin receptor. Endocrinology 150:49204930.
  • Piccoli F, Degen L, MacLean C, Peter S, Baselgia L, Larsen F, Beglinger C, Drewe J. (2007) Pharmacokinetics and pharmacodynamic effects of an oral ghrelin agonist in healthy subjects. J Clin Endocrinol Metab 92:18141820.
  • Prodam F, Bellone S, Casara G, De Rienzo F, Grassino EC, Bonsignori I, Demarchi I, Rapa A, Radetti G, Bona G. (2010) Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acid. Epilepsia 51:312315.
  • Ravizza T, Balosso S, Vezzani A. (2011) Inflammation and prevention of epileptogenesis. Neurosci Lett 497:223230.
  • Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hokfelt T, Wasterlain C, Bartfai T, Langel U. (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A 99:71367141.
  • Smolders I, Bortolotto ZA, Clarke VR, Warre R, Khan GM, O’Neill MJ, Ornstein PL, Bleakman D, Ogden A, Weiss B, Stables JP, Ho KH, Ebinger G, Collingridge GL, Lodge D, Michotte Y. (2002) Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Nat Neurosci 5:796804.
  • Soares JB, Leite-Moreira AF. (2008) Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 29:12551270.
  • Sorensen AT, Kanter-Schlifke I, Carli M, Balducci C, Noe F, During MJ, Vezzani A, Kokaia M. (2008) NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning. Hippocampus 18:564574.
  • Stevanovic D, Starcevic V, Vilimanovich U, Nesic D, Vucicevic L, Misirkic M, Janjetovic K, Savic E, Popadic D, Sudar E, Micic D, Sumarac-Dumanovic M, Trajkovic V. (2011) Immunomodulatory actions of central ghrelin in diet-induced energy imbalance. Brain Behav Immun 26:150158.
  • Tabb K, Szot P, White SS, Liles LC, Weinshenker D. (2004) The ketogenic diet does not alter brain expression of orexigenic neuropeptides. Epilepsy Res 62:3539.
  • Tena-Sempere M. (2008) Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat Clin Pract Endocrinol Metab 4:666674.
  • van Luijtelaar G, Sitnikova E. (2006) Global and focal aspects of absence epilepsy: the contribution of genetic models. Neurosci Biobehav Rev 30:9831003.
  • Vecsei L, Bollok I, Telegdy G. (1983) Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats. Peptides 4:293295.
  • Walker M. (2007) Neuroprotection in epilepsy. Epilepsia 48(Suppl. 8):6668.
  • Weinshenker D. (2008) The contribution of norepinephrine and orexigenic neuropeptides to the anticonvulsant effect of the ketogenic diet. Epilepsia 49(Suppl. 8):104107.
  • Whatmore AJ, Hall CM, Jones J, Westwood M, Clayton PE. (2003) Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf) 59:649654.
  • Xu X, Jhun BS, Ha CH, Jin ZG. (2008) Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation. Endocrinology 149:41834192.
  • Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z. (2009) Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453:5861.
  • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132:387396.