CRITICAL REVIEW AND INVITED COMMENTARY
The system epilepsies: A pathophysiological hypothesis
Article first published online: 25 APR 2012
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
Volume 53, Issue 5, pages 771–778, May 2012
How to Cite
Avanzini, G., Manganotti, P., Meletti, S., Moshé, S. L., Panzica, F., Wolf, P. and Capovilla, G. (2012), The system epilepsies: A pathophysiological hypothesis. Epilepsia, 53: 771–778. doi: 10.1111/j.1528-1167.2012.03462.x
- Issue published online: 25 APR 2012
- Article first published online: 25 APR 2012
- Accepted February 23, 2012.
- Generalized epilepsies;
- Focal epilepsies;
- Neural systems;
- Thalamo-cortical systems;
- Cortico-cortical connections
We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.