FULL-LENGTH ORIGINAL RESEARCH
Predictors for long-term seizure outcome in juvenile myoclonic epilepsy: 25–63 years of follow-up
Version of Record online: 12 JUN 2012
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
Volume 53, Issue 8, pages 1379–1386, August 2012
How to Cite
Geithner, J., Schneider, F., Wang, Z., Berneiser, J., Herzer, R., Kessler, C. and Runge, U. (2012), Predictors for long-term seizure outcome in juvenile myoclonic epilepsy: 25–63 years of follow-up. Epilepsia, 53: 1379–1386. doi: 10.1111/j.1528-1167.2012.03526.x
- Issue online: 10 AUG 2012
- Version of Record online: 12 JUN 2012
- Accepted April 7, 2012; Early View publication June 12, 2012.
- Juvenile myoclonic epilepsy;
- Long-term seizure outcome;
- Outcome predictors;
Purpose: The long-term seizure outcome of juvenile myoclonic epilepsy (JME) is still controversial; the value of factors that are potentially predictive for seizure outcome remains unclear. The aim of this study was both to investigate the long-term seizure outcome in patients with JME after a follow-up of at least 25 years and to identify factors that are predictive for the seizure outcome.
Methods: Data from 31 patients (19 women) with JME were studied. All of them had a follow-up of at least 25 years (mean 39.1 years) and were reevaluated with a review of their medical records and direct telephone or face-to-face interview.
Key Findings: Of 31 patients 21 (67.7%) became seizure-free; in six of them (28.6%) antiepileptic drug (AED) treatment was discontinued due to seizure freedom. The occurrence of generalized tonic–clonic seizures (GTCS) preceded by bilateral myoclonic seizures (BMS) (p = 0.03), a long duration of epilepsy with unsuccessful treatment (p = 0.022), and AED polytherapy (p = 0.023) were identified as significant predictors for a poor long-term seizure outcome, whereas complete remission of GTCS under AED significantly increased the chance for complete seizure freedom (p = 0.012). The occurrence of photoparoxysmal responses significantly increases the risk of seizure recurrence after AED discontinuation (p = 0.05).
Significance: This study shows conclusively that JME is a heterogeneous epilepsy syndrome. Life-long AED treatment is not necessarily required to maintain seizure freedom. Several long-term outcome predictors that can potentially increase the ability of clinicians and their confidence to recommend different treatment options to patients with JME were identified.