These authors equally contributed to data acquisition and data analysis and should be considered as joint first authors.
FULL-LENGTH ORIGINAL RESEARCH
Memory in frontal lobe epilepsy: An fMRI study
Article first published online: 5 JUL 2012
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
Volume 53, Issue 10, pages 1756–1764, October 2012
How to Cite
Centeno, M., Vollmar, C., O'Muircheartaigh, J., Stretton, J., Bonelli, S. B., Symms, M. R., Barker, G. J., Kumari, V., Thompson, P. J., Duncan, J. S., Richardson, M. P. and Koepp, M. J. (2012), Memory in frontal lobe epilepsy: An fMRI study. Epilepsia, 53: 1756–1764. doi: 10.1111/j.1528-1167.2012.03570.x
[Correction added after online publication 5-Jul-2012: Dr. O'Muircheartaigh's name has been updated.]
- Issue published online: 2 OCT 2012
- Article first published online: 5 JUL 2012
- Accepted May 14, 2012; Early View publication July 5, 2012.
- Frontal lobe epilepsy;
- Functional fMRI;
Purpose: Focal epilepsies are often associated with structural and functional changes that may extend beyond the area of seizure onset. In this study we investigated the functional anatomy of memory in patients with frontal lobe epilepsy (FLE), focusing on the local and remote effects of FLE on the networks supporting memory encoding.
Methods: We studied 32 patients with drug-resistant FLE and 18 controls using a functional magnetic resonance imaging (fMRI) memory encoding paradigm.
Key Findings: During encoding of stimuli, patients with FLE recruited more widely distributed areas than healthy controls, in particular within the frontal lobe contralateral to the seizure onset. Normal memory performance was associated with increased recruitment of frontal areas, and conversely a poor performance was associated with an absence of this increased recruitment and decreased activation in mesial temporal lobe areas.
Significance: In patients with FLE, recruitment of wider areas, particularly in the contralateral frontal lobe, appears to be an effective compensatory mechanism to maintain memory function. Impaired hippocampal activation is relatively rare and, in turn, associated with poor recognition memory.