FULL-LENGTH ORIGINAL RESEARCH
Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Integrated analysis of pooled data from double-blind phase III clinical studies
Article first published online: 6 AUG 2012
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
Volume 54, Issue 1, pages 98–107, January 2013
How to Cite
Gil-Nagel, A., Elger, C., Ben-Menachem, E., Halász, P., Lopes-Lima, J., Gabbai, A. A., Nunes, T., Falcão, A., Almeida, L. and Soares-da-Silva, P. (2013), Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Integrated analysis of pooled data from double-blind phase III clinical studies. Epilepsia, 54: 98–107. doi: 10.1111/j.1528-1167.2012.03605.x
- Issue published online: 3 JAN 2013
- Article first published online: 6 AUG 2012
- Accepted June 7, 2012; Early View publication August 6, 2012.
Figure S1. Study designs.
Figure S2. Mean and 95% CI of relative (%) reduction in seizure frequency over the 12-week maintenance period (ITT and PP populations).
Figure S3. Mean end/start of treatment ratio and 95% CI of trough (Cmin) plasma concentrations of most frequency used concomitant AEDs, carbamazepine, lamotrigine and valproic acid.
Table S1. Main baseline characteristics of study population.
Table S2. ANCOVA of seizure frequency per 4 weeks over the 12-week maintenance period (ITT and PP populations).
Table S3. Summary of treatment-emergent adverse events (TEAEs) (safety populations).
Table S4. Time to onset of treatment-emergent adverse events (TEAEs).
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